Plant sterols are naturally occurring molecules that humanity has evolved with. Herein, we have critically evaluated recent literature pertaining to the myriad of factors affecting efficacy and safety of plant sterols in free and esterified forms. We conclude that properly solubilized 4-desmetyl plant ...
Certain studies have found that use of peppermint oil seems to be most effective in relieving abdominal pain in diarrhea in people with diarrhea-predominantirritable bowel syndrome, which is often caused by multiple factors and can be hard to treat. ...
Such a cross-cutting perspective can be particularly useful when developing therapeutics targeting diseases shared between the two species such as cancer, diabetes, cognitive dysfunction, and inflammatory bowel disease. Furthermore, recognizing these differences also supports a reverse PK extrapolations from...
The nasal-brain route is a non-invasive drug delivery path that does not cause pain or burden the patient, and the self-administration method is relatively simple, so it does not impose a workload on the medical staff. Therefore, the nasal-brain route of administration can be easily applied...
The balance of your microbiota, and overall microbiome health and function, is extremely important, affecting nearly every system in your body.An imbalance (often referred to as dysbiosis) of the gut microbiome and microbiota has been connected to many issues in the body including: ...
FOXO3A dephosphorylation became impaired in resistant cells, thereby affecting target gene promoter transactivation (i.e. p27Kip1 and BIM). Cisplatin use, combined with p38α pharmacological inhibition, has also been shown to be related to decreased cancer cell viability through increasing BAX-...
Some of the utopian expectations of AI and DNN include elimination of drudgery, enabled humanism (more time with patients or doing medical tasks of importance), solving complex analytic problems, generating hypotheses and capitalizing on widening availability and richness of medical research data (data...
(FOX) transcription factor family consists of an evolutionarily conserved group of transcriptional regulators engaged in numerous functions during development and adult life. Their dysfunction has been associated with human diseases. SeveralFOXgene subgroup transcriptional disturbances, affecting numerous complex...
Previous studies have indicated POI is the single greatest factor affecting hospital length of stay (HLOS) after bowel resection [5]. In addition, ileus significantly contributes to healthcare costs in the United States where the resulting economic stress is estimated to be USD 750 million annually...
Obestatin/ghrelin ratio: A new activity index in inflammatory bowel diseases. Inflamm. Bowel Dis. 2009, 15, 1557–1561. [Google Scholar] [CrossRef] [PubMed] Moran, G.W.; Leslie, F.C.; McLaughlin, J.T. Crohn’s disease affecting the small bowel is associated with reduced appetite and ...