Unlike other species, FXII deficiency is a common hereditary factor deficiency in cats. To date, two causative feline F12 mutations have been described: p.L441CfsX119, found in a feline research colony in the United States and p.G544A, identified in 2 Japanese DSH siblings. The aim of ...
The felineF12gene was examined to identify a mutation associated with coagulation factor XII (FXII) deficiency in a litter of 6 cats, including 2 cats with severely reduced FXII activity (7.1 and 9.3%, respectively) and 4 cats with moderately reduced FXII activity (range 36.0 to 46.3%). ...
摘要: The plasma protein F XII (Hageman factor) has been shown to be linked with the plasma defence systems of coagulation, fibrinolysis, kallikrein-kinin and complement. It can be activated by surface cont被引量: 12 年份: 1990 收藏 引用 批量引用 报错 分享 ...
In hemophilia, blood clotting is disturbed by a lack of certain plasma blood clotting factors. Hemophilia B is caused by a deficiency in factor IX that may result from either the decreased synthesis of the factor IX protein or a defective molecule with reduced activity. The treatment of hemophil...
Given that tissue hypoxia is a result of aberrant tissue vascularization, cancer cells in tumors should also undergo starvation of plasma components in addition to O2 deficiency. Indeed, recent studies have revealed that the limited supply of plasma lipids, in addition to O2, is...
danazol,factor IX deficiency,hemophilia B,cats.No abstract is available for this article.doi:10.1111/j.1939-165X.1988.tb00496.xM.K. BoudreauxDepartment of Pathobiology, Department of Small Animal Surgery and Medicine, Scott-Ritchey Program, College of Veterinary Medicine, Auburn University, ...
Factor XII deficiency is a naturally occurring hereditary trait in domestic cats. We undertook phenotypic and genotypic analyses of FXII-deficient cats for comparative studies with the human disease counterpart. A retrospective review of feline submissions to our laboratory revealed that FXII deficiency ...
doi:10.1016/0300-9629(81)90062-1LewisJessica HElsevier B.V.Comparative Biochemistry & Physiology Part A PhysiologyLewis, JH (1981) Comparative hematology: Studies on cats including one with factor XII (Hage-man) deficiency. Comp. Biochem. Physiol. 68: pp. 355...
Animal models offer the best way to study the importance of a factor in vivo, however only two readily available FXII deficient models exist, i.e. the gene-manipulated mouse and our cats. This work characterizes the origin of the ...
The inheritance pattern of factor XII (Hageman) deficiency in domestic cats. Measurements of coagulation factor XII levels in F1 progeny of a cat having factor XII deficiency revealed an autosomal recessive pattern similar to that r... AB Kier,JF Bresnahan,FJ White,... - 《Canadian Journal ...