2023年9月19日，Anthos Therapeutics宣布，公司在研产品Factor XI（凝血因子XI）单抗Abelacimab，在一项名为AZALEA-TIMI 71（NCT04755283）治疗中高风险卒中的房颤患者的临床2期研究中，与标准疗法DOAC（利伐沙班）对比，，Abelacimab组出血显著减少，疗效上呈现“压倒性的优势”。Abelacimab是首个显著降低大出血的凝血...
factor XI 美 英 un.凝血因子XI;血浆促凝血酶原激酶前体 网络第十一因子
In vitro, factor XI can also be activated by factor XIIa in the presence of high molecular weight kininogen and a negatively charged surface. Factor XIa in turn activates factor IX [1]. Acquired inhibitors against factor XI have been rarely reported and are associated with autoimmune diseases ...
Twitter Google Share on Facebook factor IX Thesaurus Medical Legal Financial Encyclopedia Wikipedia Related to factor IX:factor XI n. A protein substance in blood plasma that is essential for the clotting of blood. A deficiency of this factor is the cause of Christmas disease. ...
Browse Nearby Words factor X factor XI factor XII See all Nearby Words Cite this Entry Style “Factor XI.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/factor%20XI. Accessed 11 Mar. 2025. Copy Citation ...
当因子Xa与激活络合这个过程被优化的共同因子V在凝血酶原酶复合物。因子Xa被蛋白Z依赖性蛋白酶抑制剂(ZPI)(丝氨酸蛋白酶抑制剂(serpin))灭活。由于蛋白质Z的存在,该蛋白质对因子Xa的亲和力增加了1000倍,而它不需要蛋白质Z来使因子XI失活。蛋白质Z的缺陷导致Xa因子活性增加和血栓形成。
Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism Article 31 March 2025 Safety, tolerability, pharmacokinetics and pharmacodynamics of milvexian with aspirin and/or clopidogrel in healthy participants Article Open access 18 July 2024 Engineering and evaluation...
Congenital Factor XI (FXI) deficiency shows a high variability in clinical phenotype. To date, many allele variants have been shown to cause this bleeding disorder. However, the genotype–phenotype relationship is difficult to establish. This report provides insights into this bleeding disorder. Sixtee...
Fig. 1..The structure of factor XI I. Proteolysis at arginines 334, 343, and 353 (arrows) result in activated factor XI I. The catalytic triad of factor XIIa consists of His393, Asp442, and Ser544. The darkened amino acids represent some of the artificial surface-binding region on the...
Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J. Biol. Chem. 277, 4892–4899 (2002). Article CAS PubMed Google Scholar Download references Acknowledgements Part of the experimental work was performed at the University of ...