Introduction A reversal agent for factor Xa (FXa) inhibitors, andexanet alfa, was Food and Drug Administration approved without extensive study of clinical effectiveness, due to an overwhelming demand for FXa inhibitor reversal. In this study, we aimed to describe patient selection, clinical ...
Related to factor Xa:factor IIa fac·tor Xa (fak'tŏr) The active form of factor X; it is formed from factor X by limited proteolysis via factor VIIa and tissue factor (extrinsic pathway) or factor IXa, VIIIa (intrinsic pathway). Factor Xa forms a complex with factor Va, phospholipid...
Direct factor Xa inhibitors. AnticoagulantMechanismDoseMonitoringHalf-life (h)Reversal agent Fondaparinux Indirect FXa inhibitor 0.1 mg/kg sc daily Anti-Xa levels calibrated 0.5–1 IU/mL 17–21 rVIIa Rivaroxaban Direct FXa inhibitor 15 mg PO BID×21 days→20 mg PO daily (adult...
Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo), is a Factor Xa inhibitor reversal agent indicated for patients treated with rivaroxaban and apixaban, when rapid reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.[1] It is available in lyophilized ...
Factor (F), Ixodes ricinus contact-phase inhibitor (Ir-CPI). The classes of inhibitors include monoclonal antibodies, small molecules, aptamers, anti-sense oligonucleotides, and natural inhibitors Full size image Table 1 Pharmacological and Pharmacokinetic characteristics of FXI inhibitors tested in ...
Reversal of Apixaban or Rivaroxaban AnticoagulationIVDosage based on the specific factor Xa inhibitor, dosage of the factor Xa inhibitor, and time since the patient's last dose of the factor Xa inhibitor. (See Table 1.)Table 1. Factor Xa (Recombinant), Inactivated-zhzo Dosage Based on ...
A postmarketing study of the bleeding reversal agent andexanet alfa (Andexxa; AstraZeneca) demonstrated safety and efficacy in patients experiencing acute intracerebral hemorrhage while on oral factor Xa (FXa) inhibitors. Results were presented during a plenary session at the 15th World Stroke Con...
In contrast with ATIII-dependent type FXa inhibitor, direct ATIII-independent type inhibitors, such as tick anticoagulant peptide and antistasin, showed an inhibitory effect on arterial as well as venous thrombosis models, which was comparable to the effects of thrombin direct inhibitors or ...
For each factor Xa inhibitor, a two-part randomized placebo-controlled study was conducted to evaluate andexanet administered as a bolus or as a bolus plus a 2-hour infusion. The primary outcome was the mean percent change in anti-factor Xa activity, which is a measure of factor Xa ...
The lag time is primarily determined by: levels of free tissue factor, tissue factor pathway inhibitor, factor VII, factor IX and fibrinogen. The amplification phase of thrombin is highly dependent on the number and function of platelets. Hence, the higher the platelet count in the sample, the...