Factor Xa inhibitorInferior vena cava thrombosisRabbitsZifaxabanIn recent years, oral factor Xa inhibitors have become a research focus as anticoagulant drugs. Zifaxaban is the first oral FXa inhibitor to enter clinical trials in China. The aim of this study was to determine the inhibitory effect...
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagula
Factor Xa, called tick anticoagulant peptide (TAP), has been isolated from the whole body extract of the soft tick Ornithidoros moubata, as reported by Waxman, L., et al., “Tick Anticoagulant Peptide (TAP) is a Novel Inhibitor of Blood Coagulation Factor Xa” Science, 248, 593-596 (...
Effects of the factor Xa inhibitor rivaroxaban on the differentiation of endothelial progenitor cells. BMC Cardiovasc Disord. 2023;23(1):282. Article PubMed PubMed Central CAS Google Scholar Srkalovic G, Nijim S, Srkalovic MB, Fajgenbaum D. Increase in vascular endothelial growth factor (...
(FIXa) has emerged as a promising target due to its selective regulation of the intrinsic pathway. Due to the high structural and functional similarities of these coagulation factors and their inhibitor binding modes, designing a selective inhibitor specifically targeting FIXa remains a challenging ...
In transfectedmammalian cellsinhibition of N-glycan addition by treatment withtunicamycinprevented secretion of factor VIII, whereas treatment with an inhibitor of complex oligosaccharidebiosynthesis,deoxymannojirimycin, did not affect secretion, although the specific activity of factor VIII was slightly increa...
However, no noticeable increase in the inhibitor titer was observed for these 2 participants. Therefore, the positive results for the binding antibody were not considered to be related to the study drug (Supplementary Table S21). All participants were negative for neutralizing antibodies in both the...
The advent of newer agents like Dabigatran, direct factor IIa (thrombin) inhibitor and Apixaban and Rivaroxaban, Factor Xa inhibitors may make this a little easier. What are the new therapeutic alternatives to warfarin in atrial fibrillation? More results ► Dictionary browser ? ▲ factionalism fac...
Factor Xa, -XIa; GPIIb/IIIa: Glycoprotein IIb/IIIa; HR: Hazard ratio; ICU: Intensive care unit; IL-6: Interleukin-6; IL-10: Interleukin-10; INTEM: Intrinsic coagulation pathway; Mcf: Maximal clot firmness; MAC: Membrane attack complex; MBL: Mannose- binding lectin; NFκB: Nuclear factor...
first used the MIF inhibitor ISO-1 and a MIF neutralizing antibody to test the involvement of MIF in DENV3-induced macrophage activation in vitro. Although blocking MIF did not affect viral replication in DENV3-infected human macrophages, both the secretion and mRNA synthesis of TNF-α and IL...