The Factor IX conjugates are substantially free of contamination by Factor IXa. The Factor IX conjugates have improved pharmacokinetic properties, such as increased half-life, which results in dose sparing and less frequent administration.ヘンリー,ウィリアム...
Factor IX analogues having prolonged in vivo half lifeThe invention is related to FIX analogues which have an increased circulation time in the blood stream before activation compared to that that of native FIX (and a week after injection to a patient retains at least about 5% of the FIX ...
The in vivo recovery and half-life of intermediate-purity, vapor-heated factor VII (FVII) concentrate were determined in patients having a congenital deficiency for FVII according to the 1991 guidelines of the International Society for Thrombosis and Haemostasis. A total of 11 patients received a ...
The disappearance curve of factor XIII from the plasma showed an initial rapid and then a slow component, the half-life of the slow phase being about 12 days which is considerably greater than most previous estimates. The therapeutic implications of the prolonged effect of infused factor XIII ...
The third volume of X-Factor returns Peter David to the helm and resumes the concept of the latter half of the first volume of X-Factor, where the team is a less-violent, investigative facet of the X-Men universe. The volume begins with Jamie Madrox renting an office along with Rahne ...
In summary, chimeric FX-C could have the potential to serve as rescue therapeutic agent to overcome the effect of synthetic FXa inhibitors in case of potentially life-threatening bleeding events or emergency surgical interventions. Further studies into FX-C dosing, half-life, and mitigation of FXa...
where x represents the normalized output (O) protein concentration, τ is the half-life of the protein, and G represents the regulatory effect: either \(G=\frac{T{F}^{n}}{T{F}^{n}+{K}^{n}}\) or \(G=\frac{{K}^{n}}{T{F}^{n}+{K}^{n}}\) for positive or negative ...
They reported that the radioactivity (dpm/mg tissue) measured at 1, 3, and 7 days did not decrease over time and therefore concluded that BMAA was being misincorporated into cerebral proteins generating a pool of long half-life proteins (Xie et al. 2013). While Dunlop and colleagues did ...
Summary. Background: nonacog beta pegol (N9-GP) is a glycoPEGylated recombinant factor IX (rFIX) molecule with a prolonged half-life. Objectives: To provide information on potential dose regimens for N9-GP for phase 3 pivotal and surgery trials. Methods: A population pharmacokinetic model was...
The protein has a procoagulant activity and biological half-life very similar to that of the authentic protein and, moreover, is more rapidly activated by thrombin. <IMAGE> 展开 收藏 引用 批量引用 报错 分享 全部来源 求助全文 掌桥科研 0...