Anticipatory postural adjustments (APAs) precede planned postural perturbations and minimize them with anticipatory corrections, while compensatory postural adjustments deal with actual perturbations of balance that occur as a result of suboptimal efficiency of anticipatory corrections. The process of generation...
By degrading active factors, Va and VIIIa, activated protein C acts as an endogenous anticoagulant. Independently of the thrombin-thrombomodulin pathway, protein C is effectively activated also by snake venom protein C activators (Marlar et al., 1982). They show high sequence similarity to other...
The most significant toxicity was mild elevation of the alanine amino-transferase level that occurred 7 to 10 weeks after infusion. The increase resolved over a median of 5 days with prednisolone treatment. This contrasts with results of earlier studies that used intrahepatic administration of AAV2 ...
Treatment of Hemophilia A Using Factor VIII Messenger RNA Lipid NanoparticlesHemophilia A (HemA) patients are currently treated with costly and inconvenient replacement therapy of short-lived factor VIII (FVIII) protein. Development of lipid nanoparticle (LNP)-encapsulated mRNA encoding FVIII can change ...
Purpose: The purpose of this study was to assess children's reactions to the administration of local anaesthetic injection in the mandible and in the maxilla, and to study their sensation of pain after each type of injection. Methods: Twenty-six children between the ages of 4 to 6 (mean ag...
Factor VIII/von Willebrand protein. Modification of its carbohydrate causes reduced binding to platelets. ABSTRACT KJ Kao,SV Pizzo,PA Mckee - 《Journal of Biological Chemistry》 被引量: 34发表: 1980年 Influence of Observation Floor and Building Height on Macroseismic Intensity The perception of an...
There is disclosed a method of producing a Factor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immunoglobulin G (Ig
with these results, splenic T cells from NHP treated with LV.coFVIII displayed a higher proliferative response upon in vitro culture in the presence of increasing concentration of FVIII protein, which suggests that a more pronounced T-cell response was mounted in NHP to LV.coFVIII treatment (...
Plasma vWF regulates hemostasis by facilitating platelet adhesion and coagulation factor VIII (FVIII) stabilization29,30. Subendothelial vWF mediates initial attachment of platelet to the basement membrane after EC injury31. Deficiency of vWF, either quantitative or qualitative, causes a bleeding disorder...
Allclotting factorsare synthesized by the liver.Factor VIIIis synthesized by hepatic endothelial sinusoidal cells. PT/INR indirectly determines the amount of clotting factors available and therefore is used to assess hepatic synthetic function. Elevation in PT/INR is not specific for liver disease and...