Prevalence of factor V Leiden variant in various populations. Genet Epidemiol. 1997; 14 (4):403–411.Herrmann FH, Koesling M, Schroder W, Altman R, Jimenez Bonilla R, Lopaciuk S, et al. Prevalence of factor V Leiden mutation in various populations. Genet Epi demiol 1997;14(4):...
Clinical Significance:This test detects the factor V Leiden variant, the most common cause of inherited thrombophilia; it may be used to evaluate individuals with a strong personal or family history of venous thromboembolism (VTE) and inform treatment or preventive decisions [1]. Factor V Leiden r...
The factor V Leiden (FVL) mutation is the most common cause of inherited thrombophilia in Caucasian populations, and women with this variant allele are at increased risk for pregnancy complications. To examine whether the FVL allele is associated with pregnancy complications and adverse outcomes in ...
A single base-pair mutation changing Arg506 to Gln at the APC cleavage site of the factor V gene leads to a factor V Leiden variant, which is the most frequent cause of APC resistance. Recently, its role in peripheral venous thrombosis during pregnancy was described. We here report a case...
Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 1997; 89: 2817–2821. CAS PubMed Google Scholar van de Water NS, French JK, Lund M, Hyde TA, White HD, Browett PJ . Prevalence of factor V Leiden and prothrombin variant F202...
the mutation was not found in several series of individuals with VTE or healthy controls, suggesting it is a very rare Factor V variant.173,180 A different mutation in the same codon predicting an Arg- to-Gly substitution was identified in two Chinese individuals with a history of thrombosis....
Define Factor VIIa. Factor VIIa synonyms, Factor VIIa pronunciation, Factor VIIa translation, English dictionary definition of Factor VIIa. Noun 1. factor VII - a coagulation factor formed in the kidney under the influence of vitamin K cothromboplastin,
The relevant functional rescue observed for the responsive PTC variant affecting the signal peptide was driven by the synthesis of a full-length FIX protein displaying wild-type features, as also demonstrated by expression of the corresponding readthrough-derived missense variants, due to removal of ...
A mutation in the Factor V gene (Factor V Leiden), a variant in the 5,10-methylenetetrahydrofolate reductase gene (MTHFR), and an insertion/deletion polymo... D Anne,A Harland,HW Craig,... - 《American Journal of Epidemiology》 被引量: 176发表: 0年 ...
For this, all SNPs located at +/− 100 kb from a lead variant were investigated through the use of the coloc R package. Second, we conducted a Mendelian Randomization (MR) analysis using, as instrumental variables, the lead SNPs at each locus found genome-wide significantly associated ...