GENETEST REVIEW Genetics in Medicine Factor V Leiden thrombophilia Jody Lynn Kujovich, MD TABLE OF CONTENTS Pathogenic mechanisms and molecular basis ...2 Prevalence...2 Diagnosis...
Factor V Leiden is the most prevalent genetic thrombophilia in people of European descent. Since its discovery, much clinical information has been gathered regarding the distribution and prevalence of the genetic mutation, the mechanism of thrombophilia, and its association with clinical thromboembolic ...
Define factor XIII. factor XIII synonyms, factor XIII pronunciation, factor XIII translation, English dictionary definition of factor XIII. Noun 1. factor XIII - in the clotting of blood thrombin catalyzes factor XIII into its active form which causes fi
factor V Lei·den -ˈlī-dᵊn 1 : a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood 2 also factor V Leiden thrombophilia : a genetic disorder caused by factor V Leiden that is marked by an ...
Inappropriate Testing and Treatment of Factor V Leiden and Other Heritable ThrombophiliasScott J. Parsons DO aSven R. Olson MD bThomas G. DeLoughery MD, MACP, FAWM bThe American Journal of Medicine
Thrombophilia in infancy: factor V Leiden and MTHFR or factor II double heterozygocity as a risk factor. Pediatr Hematol Oncol 2003;20:219-27.Koren A, Levin C, Hujirat Y, El-Hasid R, Kutai M, Lanir N, Shalev S, Brenner B (2003) Thrombophilia in infancy: factor V Leiden and MTHFR...
Clinical Significance:This test detects the factor V Leiden variant, the most common cause of inherited thrombophilia; it may be used to evaluate individuals with a strong personal or family history of venous thromboembolism (VTE) and inform treatment or preventive decisions [1]. ...
The thrombosis varies from localized cutaneous involvement to catastrophic thromboembolism and is usually associated with an underlying thrombophilia. We describe a patient who developed skin necrosis during warfarin treatment for a pulmonary thromboembolism. The management was complicated by the development of...
Factor V LeidenFVLProthrombinThrombophiliaWe report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are...
Leiden mutation as a risk factor for recurrent pregnancy loss. Ann Intern Med 1998; 128: 1000–1003. Article CAS Google Scholar Brenner B . Inherited thrombophilia and pregnancy loss. Thromb Haemost 1999; 82: 634–640. Article CAS Google Scholar Eldor A . The treatment of thrombosis during...