Prevalence of FV Leiden varies; however, heterozygosity for the FV Leiden mutation is recognised as the most common heritable thrombophilic defect in Caucasian populations. The association this inherited thrombophilia has with venous thromboembolism (VTE) is well established. Pregnancy is notably an ...
factor V Lei·den -ˈlī-dᵊn 1 : a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood 2 also factor V Leiden thrombophilia : a genetic disorder caused by factor V Leiden that is marked by an ...
and other activated coagulation markers.7–9 The mutant Factor V is referred to as Factor V Leiden because Dutch investigators from the city of Leiden were the first to report the mutation.2 PREVALENCE Factor V Leiden is the most common inherited form of inherited thrombophilia, accounting for ...
Objective Recent studies suggest an increased prevalence of obstetric complications in female carriers of hereditary or acquired thrombophilias. The aim of the study was to determine if carriership of the factor V (FV) Leiden mutation (activated protein C [APC] resistance) is higher in women who...
Twitter Google Share on Facebook (redirected fromFactor V Leiden mutation) Thesaurus Medical Legal Acronyms Encyclopedia mu·ta·tion (myo͞o-tā′shən) n. 1.The act or process of being altered or changed. 2.An alteration or change, as in nature, form, or quality. ...
Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of th...
The factor V Leiden (FVL) mutation is the most common cause of inherited thrombophilia in Caucasian populations, and women with this variant allele are at increased risk for pregnancy complications. To examine whether the FVL allele is associated with pregnancy complications and adverse outcomes in ...
Factor V Leiden Thrombophilia Causing Recurrent Thrombosis Normal hemostasis requires a delicate balance between the natural procoagulant and anticoagulant systems. Thrombophilia is an abnormality of the coagulatio... M Atiquzzaman,ASE Alam,Muhammad Mazharul HoqueMd Motiul IslamTarikul HamidMohammad Rabiul...
Activated protein C (APC) resistance, both in its congenital form, due to the factor V Leiden mutation, and in its acquired form, are important risk factor... R Rai,A Shlebak,H Cohen,... - 《Human Reproduction》 被引量: 350发表: 2001年 Thrombophilias and Recurrent Pregnancy Loss were...
Factor V Leiden (l691G-+A) has been described as a major cause of predisposition to thromboembolism as the mutation creates resistance to the anticoagulant activity of activated protein C (APC). Women who carry inherited thrombophilias are at much higher risk to have clotting problem leading to...