The factor V Leiden mutation is a recently described autosomal dominant genetic risk factor for venous thromboembolism (VTE). Persons who are heterozygous or homozygous for this disorder are at 4 to 7 times and 50 to 100 times increased risk, respectively, for VTE. In particular, women have ...
Activated protein C resistance, caused by a point mutation factor V gene was described in last decade. This article highlights a case of a 9 year-old-boy who admitted to Ba艧kent University Hospital with right- sided hemiplegia. He was diagnosed as heterozygous for the FVL muta- tion and ...
(redirected fromFactor V Leiden mutation) Thesaurus Medical Legal Acronyms Encyclopedia mu·ta·tion (myo͞o-tā′shən) n. 1.The act or process of being altered or changed. 2.An alteration or change, as in nature, form, or quality. ...
We report here the evolution of the thrombin generation profile while taking combined oral contraceptives and after their discontinuation in a woman with heterozygous factor V Leiden mutation. The proband exhibited a distinctly prothrombotic thrombin generation profile including markedly decreased thrombomodulin...
Synonyms for Factor V Leiden mutation in Free Thesaurus. Antonyms for Factor V Leiden mutation. 34 synonyms for mutation: anomaly, variation, deviant, freak of nature, change, variation, evolution, transformation, modification, alteration, deviation...
Factor V Leiden refers to the c.1691G>A variant in the FV gene, which encodes coagulation factor V. This variant results in resistance to factor V protein degradation by activated protein C and increases the risk of VTE 6 to 8 fold in heterozygous carriers and 80 fold in homozygous carrier...
No statistically significant association was found between patients with systemic involvement (26.7%) and without systemic involvement (16.4%) with respect to FVL gene mutation (p=0.197). All of the patients and controls tested positive were heterozygous for the mutation.Conclusion: Further studies in...
We report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are rare. Of eight reported cases of ...
Of these patients, 21 were considered at high risk for thrombosis, but none was found to carry the mutation. One patient (0路4 per cent) of the total was heterozygous for the Factor V Leiden mutation. African-American women do not appear to be at an increased risk of being hetero...
The results of the present study showed that the incidence of blood clotting factor V Leiden mutation was found in 8 (16%) patients, from which 7 (14%) patients had heterozygous mutant and 1 (2%) had homozygous mutant for FV, the remaining patients (84%) were don't have FV Leiden (...