DNA-dependent formation of transcription factor pairs alters their binding specificity Nature, 527 (2015), pp. 384-388 Google Scholar 11 P. Li, R. Spolski, W. Liao, L. Wang, T.L. Murphy, K.M. Murphy, W.J. Leonard BATF-JUN is critical for IRF4-mediated transcription in T cells ...
A cis-acting element, located 3646 base pairs upstream of the start of tyrosine aminotransferase gene transcription, has been found to be sufficient to reproduce these variations with heterologous genes and promoters (Oshima, H., and Simons, S.S., Jr. (1992) Mol. Endocrinol. 6, 416-428)....
During the interaction of a T cell with an antigen-presenting cell (APC), several receptor ligand pairs, including the T cell receptor (TCR)/major histocompatibility complex (MHC), accumulate at the T cell/APC interface in defined geometrical patterns. This accumulation depends on a movement of...
Transcription factors (TFs) control cell identity and function. How their activity is altered during healthy aging is critical for an improved understanding of aging and disease risk, yet relatively little is known about such changes at cell-type resolut
Enhancing drought tolerance in crops and understanding the underlying mechanisms have been subject of intense research. The precise function and molecular mechanisms of B-box zinc finger proteins (BBX) remain elusive. Here, we report a natural allele of
Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for regions with depletion of cleavage events due to transcription factor binding, is poorly u
This might expand the repertoire of possible Six2 binding sites and explain why it is not possible to delineate a consensus sequence for Six protein binding sites from the sequences published to date. Even the two pairs of binding sites reported here do not show a significant similarity and ...
Using the network topologies predicted by Taiji, the ratio of gene expression between all pairs of topologies (response) was predicted based on the ratio of expression levels of their specific parent TFs (features). We then validated the network by confirming the predicted gene expression differences...
After residualisation, we excluded from the analysis all those metabolites pairs for which the absolute value of their correlation was less than 0.5. We then tested for differential co-abundance between pairs of metabolites similarly to previous work33 by using the Fisher R to Z transformation as...
A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucleic acids encoding naturally oc...