ADASTRA generates two complementary data sets: transcription factor ASBs (pairs of an SNP and a TF) and cell type ASBs (pairs of an SNP and a cell type). SNPs are annotated according to dbSNP IDs. c, d Number of SNPs (dbSNP IDs, Y-axis) with significant ASB events for various ...
Transcription factor binding sites (TFBSs) are important sources of evolutionary innovations. Understanding how evolution navigates the sequence space of such sites can be achieved by mapping TFBS adaptive landscapes. In such a landscape, an individual l
et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor OCT4. Cell 95, 379–391 (1998). Article CAS PubMed Google Scholar Jolma, A. et al. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527, ...
Transcription factors (TFs) play key roles in the regulation of gene expression by binding in a sequence-specific manner to genomic DNA. In eukaryotes, DNA binding is achieved by a wide range of structural forms and motifs. TFs are typically classified b
Further N-terminally positioned residues, one asparagine, alanines and other amino acids, make specific contacts with DNA base pairs and are responsible for the recognition of the DNA target sequence. The stem of the Y consists largely of the leucine zipper dimerization region that extends away ...
How many cubic meters of milk are in 9.81 qt (1 qt=946.4 mL). Enter your answer in scientific notation. What conversion factor would you use to convert between these pairs of units? a) minutes to hours. b) grams to milligrams. c) cubic decimeters to milliliters. Perform t...
Different pairs of constructs were introduced into yeast strain AH109 as described in the article, and the cells were grown on SD-Trp/-Leu medium. Then, three single clones from SD-Trp/-Leu plates were transferred to SD-Trp/-Leu/-His and SD-Trp/-Leu/-His/-Ade plates. Yeast growth ...
The topological overlap measure (TOM) calculated by WGCNA was used as a measure of co-expression for pairs of genes. Prior to visualization, the overall network size was reduced in two ways. First, all gene pairs were filtered by requiring one of the two genes to be a tran- scription ...
(pairs of an SNP and a cell type). SNPs are annotated according to dbSNP IDs.c,dNumber of SNPs (dbSNP IDs,Y-axis) with significant ASB events for various transcription factors and for various cell types. TFs or cell types (X-axis) are sorted by the number of SNPs. SNP single-...
5c). This is not a result of ascertainment bias because such bias would lead to the opposite result: there is greater statistical power to detect weak, distant, eQTL associations for highly expressed genes. In fact, this phenomenon holds true for most pairs of GTEx tissues with available H3K...