A target vector is represented as a 690 \(\times \)1 binary vector where each element of the vector corresponds to one experiment out of the 690 ChIP-seq experiments. A ChIP-seq experiment can be represented as a TF-cell line pair (e.g., HepG2-p300). 172 TFs and 92 cell lines ...
The CES-D 8 was used to measure depressive symptoms [22]. The participants were asked how often they experienced some mental state in the past week, with a 4-point rating scale, ranging from 1 (Never, less than one day) to 4 (most of the time, 5–7 days). 2 of the 8 items (...
3h,i): enrichment analysis of 22YtoS cells uncovered enriched proteins in several categories related to nuclear transport. Five nucleoporins were identified among the top 75 most enriched proteins (Fig. 2e, Extended Data Fig. 3h and Supplementary Data Table 1). To validate these observations, ...
The region of the keratin 14 gene sufficient and required for repression by Skn-1a is a 100-base pair sequence lacking POU-binding sites adjacent to the transcription start site. DNA-binding defective mutants of Skn-1a and Tst-1 are as effective at mediating repression as the wild type ...
vinifera. Notably, we identified at least one pair of collinear genes (i.e., CqSPL21 and Solyc05g015840/ EER97011/AT5G50670.2/VIT_14s0068g01780/BGIOSGA005075/Zm00001d021056), which may provide a theoretical basis for understanding their ancestry. Moreover, an analysis of orthologous genes...
1B) (22, 23, 24, 25, 26, 27, 28). CaM is composed of two four-helix bundle domains (CaMN and CaMC). They are connected by a flexible linker that allows the domains to move independently in solution. Both CaMN and CaMC contain a pair of EF-hands that bind Ca2+ cooperatively. ...
This work documents the spatial development of a triad of instability waves consisting of a plane TS mode and a pair of oblique modes with equal-opposite w... T. C. Corke,S. Gruber - 《Journal of Fluid Mechanics》 被引量: 82发表: 2006年 Numerical and experimental study of turbulent impi...
In our approach, a first adjustment we made is to replace the simple Parzen window function of Eq. 3 with a smoother window function: [Math Processing Error]ϕx,l,h=12πh/22exp-l-x22h/22 (4) That is, ϕ is a Gaussian function fit over each position x in the set of promoter...
of metabolic disease in the context of KLF2 deletion, we employed two methods of central nervous system (CNS) macrophage manipulation. To control for the effects of increased food intake on the K2KO phenotype (Fig.2b), we utilized a pair-feeding model in which the amount of HFD given to ...
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome-wide binding data for 38 transcription factors w