The original CES-D consisted of 20 items, measuring four factors including “depressed affect”, “positive affect”, “somatic and retarded activity” and “interpersonal” [19]. The scale was widely used in the Chinese context and showed adequate reliability and validity [20, 21]. However, ...
FGF21 is a hormonal factor with important functions in the control of metabolism. FGF21 is found in rodent and human milk. Radiolabeled FGF21 administered to lactating dams accumulates in milk and is transferred to neonatal gut. The small intestine of neonatal (but not adult) mice highly expres...
Transcription factors (TFs) regulate the gene expression of their target genes by binding to the regulatory sequences of target genes (e.g., promoters and enhancers). To fully understand gene regulatory mechanisms, it is crucial to decipher the relationships between TFs and DNA sequences. Moreove...
In general, a multivariate Gaussian (each component in the GMM) models pairwise correlations between the different data dimensions. If the dimension of the data samples is d, the covariance matrix size will be d by d, making it impractical to store and invert for high-dimensional data such ...
and the SCF dimer the horizontal bar. Analysis of the interactions of each SCF with its partner c-Kit identified three binding epitopes. Approximately 2200Å2of solvent-accessible surface is buried between each pair of SCF and KIT. This contact area can be subdivided into 610Å2for site 1,...
Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has different binding properties on two IR isoforms, mimicking insulin’s function. However, the molecular mechanism underlying IGF2-induced IR activation remains u
Immune-related gene polymorphisms as risk factors for the development of Factor VIII inhibitors in hemophilia A patients: a sibling-pair association analysis (HUM1P.257) Inhibitors are one of the most feared complications in hemophilia, occurring in 15-30% of individuals with severe forms of Hemoph...
vinifera. Notably, we identified at least one pair of collinear genes (i.e., CqSPL21 and Solyc05g015840/ EER97011/AT5G50670.2/VIT_14s0068g01780/BGIOSGA005075/Zm00001d021056), which may provide a theoretical basis for understanding their ancestry. Moreover, an analysis of orthologous genes...
This study identified and mapped the chromosomal positions of all MsARF genes to investigate whether there was a collateral homologous gene pair relationship between the MsARFs in alfalfa (Fig. 4). The 81 MsARF genes were unevenly distributed on 25 chromosomes (Chr) and seven other chromosomes ...
CaM is composed of two four-helix bundle domains (CaMN and CaMC). They are connected by a flexible linker that allows the domains to move independently in solution. Both CaMN and CaMC contain a pair of EF-hands that bind Ca2+ cooperatively. In free CaM, CaMC has an affinity for Ca2+...