contributing to mortality. Therapy still remains mainly supportive. We assessed risk factors in retrospective analysis of 192 autologous peripheral stem cell transplantation patients with lymphoma and multiple myeloma (MM), respectively. Futhermore, we examined the hormone...
Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic target for castration-resistant prostate cancer, is key for its activity as transcription factor, allowing it to translocate to the nucleus and partition into transcriptional condensates upon ...
From time differential γ-ray measurements following the reaction 62Ni(d,p) 63Ni ∗, the results E γ = 87.2 ± 0.4 keV, τ = 2.48 ± 0.04 ωs, g = +0.296 ± 0.001 are obtained for the first excited state in 63Ni. The applicability of this level in the field of nuclear solid...
Production of competence-provoking factor and transformation of a group H streptococcus were achieved in the absence of serum or albumin in media sterilized by filtration through Millipore filters.No significant transformation was found when the medium was heated more than 40–50 minutes at 115°117 ...
Recently we have established an association between mast cells and local thrombus formation. The most useful model for studying molecular mechanisms of mast cell-thrombosis interactions appeared to be auricular thrombosis. In the present review we summarize our findings in patients with auricular ...
[63] found a PPAR agonist decreased the expression of apoptotic markers in rats with cerebral ischemia–reperfusion injury. Liu et al. [26] suggested the PPARγ agonist pioglitazone protected against IL-17-induced IVD inflammation and degeneration via regulation of the NF-κB signaling pathway, whi...
The renovation of residential buildings usually involves a variety of measures aiming at reducing energy and building maintenance bills, increasing safety and market value, and improving comfort and aesthetics. A significant number of project appraisal methods in current use—such as calculations of payba...
The Driver Behavior Questionnaire (DBQ) is a self-report measure of driving behavior that has been widely used over more than 20 years. Despite this wealth of evidence a number of questions remain, including understanding the correlation between its violations and errors sub-components, identifying ...
The first member of the velvet family of proteins, VeA, regulates sexual development and secondary metabolism in the filamentous fungus Aspergillus nidulans. In our study, through comparative proteome analysis using wild type and veA-deletion strains, ne
Ageing is the main risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD). Tissues composed primarily of postmitotic cells, such as the brain, are especially sensitive to the effects of ageing. Hallmarks of ageing — genomic instability, telomere...