eIF3e has been described in various types of human cancer but the nature of its involvement in tumorigenesis is still not completely resolved. MMTV insertion results in truncated eIF3e protein in MCF10A (mammary epithelial cells), NIH 3T3 (mouse embryonic fibroblast cell line) and alveolar ...
7D). Antibody-triggered conversion of the S2302 substrate was completely dependent on FXII and was absent in FXII-deficient plasma (Fig. 7E). Enzymatic activity induced by mAb-αPR-III_37 was blocked by FXIIa inhibitor corn trypsin inhibitor (2 µM) to background levels. Supporting ...
In addition, a single administration of inhibitor-insensitive FX could potentially be sufficient to completely restore hemostasis, as the circulatory half-life of FX (34–40 h) exceeds that of the direct FXa inhibitors apixaban (~12 h) and edoxaban (10–14 h)2, 45, 46. Moreover, ...
It is apparent from the results that MoAb 5F7 can completely block factor XI binding to HMW kininogen and that 50% inhibition of binding occurred at approximately 5 × 10−10 mol/L 5F7 (ie, close to the kd for binding of 5F7 to factor XI as determined above). However, 100-fold ...
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 2001;21:1393–403. Article CAS PubMed PubMed Central Google Scholar Ishida H, Kuruta Y, Gotoh O, Yamashita C, Yoshida Y, Noshiro M. ...
Answer to: completely factor p(x)=3x^3-8x^2-31x+60 into linear factors, given that -3 is a zero By signing up, you'll get thousands of...
Factor the expression: 15a^2(b - 2)^2 + 20a^3(b - 2)^3. Completely factor the following expression: 2(x + 1)(x - 3)2 - 3(x + 1)2(x - 3) Factor the expression: 3x^{\frac{3}{2 - 9x^{\frac{1}{2 + 6x^{\frac{-1}{2 ...
2e; Additional file 6: Figures S5A and S5B). The integrin signaling-induced IGF-1R and Src phosphorylation was completely abolished by dasatinib treatment. These findings suggest that multiple membrane-associated receptors, including EGFR and integrin, can phosphorylate IGF-1R via Src activation. ...
Its value ranges from 0 to 1, with 0 meaning the genotype and status are independent and 1 meaning the genotype completely determines the status. Also, as NMI provides a direct information theoretical measure of association, it may be preferred over the likelihood ratio test statistic, which ...
Despite its functional importance, how YY2’s DNA-binding activity and function are regulated, particularly by PTMs, remains completely unknown. Here we report the first PTM with functional characterization on YY2, namely lysine 247 monomethylation (K247me1), which was found to be dynamically ...