The original CES-D consisted of 20 items, measuring four factors including “depressed affect”, “positive affect”, “somatic and retarded activity” and “interpersonal” [19]. The scale was widely used in the Chinese context and showed adequate reliability and validity [20, 21]. However, ...
g, Transcriptional activity (average ± s.e.m.) of AR and Tyr to Ser mutants, assessed using a luciferase reporter assay for AR (tDHT = 1 h, top) or AR-V7 (bottom) in HEK293 cells. Empty stands for empty vector, and P were calculated using a Dunnett’s multiple-comparison test...
Physical activity and exercise attenuate neuroinflammation in neurological diseases. Brain Res. Bull. 125, 19–29 (2016). CAS PubMed Google Scholar Bekris, L. M., Yu, C. E., Bird, T. D. & Tsuang, D. W. Genetics of Alzheimer disease. J. Geriatr. Psychiatry Neurol. 23, 213–227 ...
UFH and Fondaparinux demonstrated complete or near complete inhibition with identical EC50 values at both tissue factor concentrations, suggesting that inhibition of intrinsic tenase activity does not significantly contribute to their mechanism of action in plasma. In contrast, LMWH and ssLMWH demonstrated...
As will be discussed later, PTH promotes osteoblast survival in part by increasing Runx2 activity and consequently inducing expression of the survival gene Bcl2. However, PTH also induces proteasomal degradation of Runx2 through a mechanism involving Smurf2. Therefore, the ability of PTH to either...
Astrocytes are abundant, conserved CNS cells that maintain normal CNS function, support the blood-brain barrier, and modulate synaptic activity[8, 9]. Astrocytes also play roles in the progression of various neurological diseases[10]. Astrocyte reactivity is an early feature of Alzheimer’s disease...
ARF transcription factors and auxin/indole-3-acetic acid (Aux/IAA) protein dimers can inhibit ARF-regulated transcriptional activity in the presence of low auxin concentrations, but the degree of expression inhibition is only moderate [11]. When the auxin concentrations are high, the 26 S ...
the transcriptional activity of SlDof1 onNR,NOR,MC,SlDIV2, andSlREV8was not detected. It remains possible that the transient transcription assay conducted inN. benthamianaleaves does not completely reflect the regulatory activity of SlDof1 in fruits, which are more complicated thanN. benthamianaleav...
Sections were incubated in H2O2 solution (1% in 20% methanol, 20 min, room temperature) to quench endogenous peroxidase activity, rinsed in PBS, incubated with citrate-Na (pH 6.0) to facilitate antigen retrieval (2 × 5 min in the microwave) and washed in TBS (3 × 5 min). ...
implies a different turn-over rate of MFG-E8 with or without associated EVs. Phagocytes and macrophages are presumably the main cell population responsible for the degradation of MFG-E8. Further investigation may be needed to clarify whether phagocytic activity is accelerated or not in patients ...