The original CES-D consisted of 20 items, measuring four factors including “depressed affect”, “positive affect”, “somatic and retarded activity” and “interpersonal” [19]. The scale was widely used in the Chinese context and showed adequate reliability and validity [20, 21]. However, ...
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Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic target for castration-resistant prostate cancer, is key for its activity as transcription factor, allowing it to translocate to the nucleus and partition into transcriptional condensates upon ...
Now, finally, you can look at the High Level Shader Language (HLSL) code that’s doing much of the work in rotating the vertices of those three triangles and orienting them in 3D space. This is the new and improved vertex shader, shown in its entirety inFigure 4. ...
Astrocytes are abundant, conserved CNS cells that maintain normal CNS function, support the blood-brain barrier, and modulate synaptic activity[8, 9]. Astrocytes also play roles in the progression of various neurological diseases[10]. Astrocyte reactivity is an early feature of Alzheimer’s disease...
By reversibly engaging the active site of FXa with high affinity, the small molecules effectively block the catalytic activity of both free and prothrombinase-assembled FXa. However, a major drawback to their use is the absence of an adequate reversal strategy to prevent and stop potential life-...
However, the metabolite 15-deoxy-δ12,14 PGJ2 also can exhibit anti-inflammatory activity in a PPARγ-independent manner. PPARα is expressed mainly in tissues that have a high fatty acid catabolism including liver and the immune system. LTB4 is an activator and natural ligand of PPARα.96 ...
A potential problem with these soluble growth factors is rapid diffusion away from the site where activity is requiredin vivo. The duration of growth factor activity may be prolonged by incorporating these soluble factors within a scaffold delivery vehicle. In our recent study, we have ...
Espley RV, Hellens RP, Putterill J, Stevenson DE, Kutty-Amma S, Allan AC (2007) Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10. Plant J 49:414–427 Article CAS PubMed PubMed Central Google Scholar Sundaramoorthy J, Park GT, Lee J-...
the control oligonucleotides had no effect on the transformed phenotype of the cells, while SF2i2 had an obvious effect (Supplementary Fig.11A-C). To verify that the observed reduced oncogenic activity is due to activation of the p38-MAPK stress pathway, we used the p38-MAPK inhibitor SB203580...