Factor VIII is a complex of two components: a low-molecular weight part possessing factor VIII procoagulant activity, and a high-molecular weight carrier protein-vWF which is required for the normal hemostatic function of the platelets [30]. vWF acts as a carrier protein for factor VIII in pla...
Rheumatoid factor is an antibody that is measurable in the blood with a routine blood test. Rheumatoid factor is actually an antibody that can bind to other antibodies. Antibodies are normal proteins in our blood that are important parts of our immune system. Rheumatoid factor is an antibody tha...
Astrocytes are abundant, conserved CNS cells that maintain normal CNS function, support the blood-brain barrier, and modulate synaptic activity[8, 9]. Astrocytes also play roles in the progression of various neurological diseases[10]. Astrocyte reactivity is an early feature of Alzheimer’s disease...
we analyzed 185 patients who underwent primary curative hepatic resection for HCC with complete blood test for both AFP and DCP, and who had been observed for more than 5 years after initial curative resection
The test of blood factorSOURAV K. KUNDU
To test this hypothesis, we decided to evolve recombinases targeting sequences that are implicated in a disease-causing inversion of the F8 gene (ID: 2157, Homo sapiens). The resulting disease is a severe form of a blood clotting defect (Hemophilia A) where no Factor VIII activity is ...
Acute myeloid leukemia cells from seventy-two patient bone marrow or blood samples Normal aging Cells from relapsed human acute myeloid leukemias after initial treatment with anthracycline-containing regimens exhibited significantly reduced TOP2B activity. Gieseler et al., 1996 [39] Wild-type C57BL/6 ...
HIF1A was reported as a target of MIR17HG in lung cancer cells, but the specific role of miR-18a in the control of HIF1A expression and activity was not tested [40]. We found that miR-18a, along with other family members encoded by MIR17HG, was downregulated in breast cancer cells ...
The bleeding tail was immersed in a 15 mL test tube containing 12 mL pre-warmed PBS. Bleeding time was recorded as the time to cessation of bleeding for 10 s67. Blood loss was quantified by measuring the haemoglobin content of blood collected into PBS. Following centrifugation, the ...
(NMDAR) functions3,4,5. Systemic elevation of KL in mice increases synaptic plasticity, cognition and neural resilience to aging, Alzheimer’s and Parkinson disease-related toxicities3,10,11,12,13,14. Notably, systemic administration of KL does not cross the blood–brain barrier as measured by...