Factor V Leiden deficiency?doi:10.1111/j.1651-2227.2002.tb00116.xK McFaddenK McFaddenActa Paediatrica
We investigated the presence of the gene mutation of factor V, FV ^l)6Q or factor V Leiden, responsible for activated protein C resis- nce, in DNA samples of 127 probands and 188 relatives from 128 jinhes with antithrombin deficiency.The factor V mutationwas iden- ned in 18 families. Ni...
Methods: Newborns from 22 pregnant women with thrombophilia (Factor V Leiden (FVL), n=16; anticardiolipin antibodies, n= 3; lupus anticoagulant, n=1; protein C deficiency, n=1; prothrombin G20210A mutation, n=1) were enrolled into the study. All women were treated with low-molecular-...
蛋白别名:Activated protein C cofactor; Coagulation factor V; coagulation factor V (proaccelerin, labile factor); coagulation factor V jinjiang A2 domain; Factor 5; factor V Leiden; Factor5; Proaccelerin, labile factor 基因别名:F5; FVL; PCCF; RPRGL1; THPH2 ...
Factor V Leiden mutation is a common genetic risk factor for venous thrombosis. It has been documented in up to 65% of patients with unexplained venous thromboembolism. This genetic mutation is now known to be the most common inherited cause of activated protein C (APC) resistance. Recently, ...
In white populations, the factor V Leiden defect is present in 5–7% of the normal population and accounts for more than 95% of the total APC resistance. Although APC resistance due to factor V Leiden has a well-recognized association with cerebral venous thrombosis,15 the relationship to ...
Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. Patients with inflammatory bowel disease have an increased frequency of thromboembolism, and microvascular thrombosis has been proposed as a contributory p... Jackson,L. - 《Qjm Monthly Journal of the...
The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation. BACKGROUND: Point mutations in the factor V gene (factor V Leiden) and the prothrombin gene (the substitution of A for G at position 20210) are the most co...
Three of 5 had combined PS deficiency and FV Leiden suggesting that, as with previous studies, FV Leiden may be an additional risk factor for thrombosis in these individuals. Although the numbers available for study were small, the low incidence of thrombosis in affected members of kindred 1, ...
Factor V Leiden: F5; 1q23. Factor II: F2; 11p11-q12. FV/PT 2.2 OMIM number. Factor V Leiden: 227400. Factor II (also referred to as Prothrombin): 176930 (See Table 1) FV/PT 2.3 Brief clinical description. The annual incidence of venous thromboembolism (deep vein thrombosis and pul-...