The risk of cerebral vein thrombosis is increased 3- to 5-fold in Factor V Leiden heterozygotes.59,46 A Factor V Leiden allele is associated with a 6-fold increased risk for superficial vein thrombosis.60 Risk for a first VTE The relative risk for VTE is increased 3- to 8-fold in ...
Andreassi MG, Botto N, Maffei S (2006). "Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening.".Clin. Chem. Lab. Med.44(5): 514-21. doi:10.1515/CCLM.2006.103. PMID 16681418.
Leiden. Heterozygosity for Factor V Leiden occurs in 3 - 8% of the general US population. The risk factors for hematologic complications are poorly understood in these donors and are difficult to assess. At present time it is uncertain whether these hematological lab abnormalitie...
(epistaxis), GI tract; peripheral nerve lesions–femoral–iliopsoas muscle, sciatic–buttock; tibial–calf; perineal–anterior leg compartment; median & ulnar–forearm flexors; high-risk hemorrhages–intracranial, intraspinal, retropharyngeal, retroperitoneal; hematuria Lab ↑ PTT, ↓ factor IX, normal ...
Procoagulant and anticoagulant properties of coagulation factor V: factor V Leiden (APC resistance) caus- es hypercoagulability by dual mechanisms. J Lab Clin Med 1999;133:415-22.Dahlback B.Procoagulant and anticoagulant properties of coagulation factor V: factor Leiden(APC resistance) causes hyper...
de Pater at Leiden University for providing parp1 and parp2 mutant seeds, and thank Dr. Ping Xu at University of East Anglia and Dr. Jeremy D. Murray in John Innes Centre for manuscript revision. Dr. Xinsheng Gu also gives helpful suggestions for the revision of the manuscript. Author ...
We define cell contexts for JRL by clustering cells using Leiden clustering [49], with a resolution \(=0.2\), generating 7 clusters (Additional file 1: Fig. S11A-B). The PBMC SupirFactor model was trained using JRL on ATAC masked data (epochs = 400) and subset to the most explanatory...
Lincz LF, Adams MJ, Scorgie FE et al. (2007) Polymorphisms of the tissue factor pathway inhibitor gene are associated with venous thromboembolism in the antiphospholipid syndrome and carriers of factor V Leiden. Blood Coagul Fibrinolysis 18(6): 559–564 ...
Clinical utility of factor V Leiden (R506Q) testing for the diagnosis and management of thromboembolic disorders. Arch Pathol Lab Med 2002;126:1304 –1318. 12. Jick H, Derby LE, Myers MW, Vasilakis C, Newton KM. Risk of hospital admission for idiopathic venous thromboembolism among users of...
Richmond for help in drawingFig. 4, and I. Hagan and S.-H. Yang for comments on the manuscript. The author is a research fellow of the Lister Institute of preventive medicine, and research in his lab is funded by the Wellcome Trust, Medical Research Council and Cancer Research Campaign ...