Factor V leiden (FVL) is an abnormality of factor V (FV), a blood coagulation factor. It is a hereditary blood coagulation disorder with a high frequency (3–7% of general population). The most common type of FVL is caused by a single amino acid mutation and, therefore, its diagnosis ...
Introduction: The discovery of the factor V Leiden (FVL) missense mutation (Arg506Gln) causing factor V resistance to the anticoagulant action of activated protein C was a landmark that allowed a better understanding of the basis of inherited thrombotic risk. FVL mutation is currently the most ...
David M, Manco-Johnson M, Andrew M (1995) Diagnosis and treatment of venous thrombo-embolism in children and adolescents. On behalf of the subcommittee on peri-natal haemostasis of the scientific and standardization committee of the ISTH. Thomb Haemostas 74: 791–792 CAS Google Scholar Faioni...
Factor V基因上的鸟嘌呤G突变为腺嘌呤A,造成第506上的谷氨酰胺被精氨酸替代,这样就形成了突变基因Factor V Leiden(FVL)。FVL会使凝血酶蛋白C(APC)的活性作用遭到抵抗,从而使血液的凝血功能异常,血栓形成倾向和高凝状态[6-7]。在对神经痛诱发的下颌齿槽骨坏死病例分析中,发现FVL突变率在患者中(24%)远远高于健康...
The clinical expression of Factor V Leiden is influenced by the number of Factor V Leiden alleles, coexisting genetic and acquired thrombophilic disorders, and circum- stantial risk factors. Diagnosis requires the activated Protein C resis- tance assay (a coagulation screening test) or DNA analysis ...
Aim of this study was to investigate whether factor V Leiden is a risk factor for myocardial infarction in northeast Turkey. Methods: We studied 112 patients who had a diagnosis of acute MI (94 males and 18 females, aged 55 ± 10 years), and 95 control subjects. The study population was...
Clinical utility of factor V Leiden (R506Q) testing for the diagnosis and management of thromboembolic disorders. Arch Pathol Lab Med 2002;126:1304 –1318. 12. Jick H, Derby LE, Myers MW, Vasilakis C, Newton KM. Risk of hospital admission for idiopathic venous thromboembolism among users of...
Leiden) that not only renders FVa less susceptible to the proteolytic inactivation by APC but also impairs the anticoagulant properties of FV. This G1691A point mutation inF5results in an arginine to glutamine substitution at amino acid 506, the site where APC cleaves FVa.217Thefactor V Leiden...
Double-Homozygosity for Factor V Leiden and the Prothrombin Gene G20210A Variant in a Young PatientWith Idiopathic Venous Thrombosis Blood, 94 (5) (1999), pp. 1828-1829 Google Scholar [3] G.M. Wulf, V.M. Van Deerlin, D.G. Leonard, K.A. Bauer Thrombosis in a patient with combined...
Rivaroxaban Causes Missed Diagnosis of Protein S Deficiency but Not of Activated Protein C Resistance (Factor V Leiden) A second-generation APC resistance test was performed on all included patients with a STACLOT[R] APC-R reagent set (Diagnostica Stago) with modifications; 100 [micro]L of pre...