Factor V Leiden deficiency?doi:10.1111/j.1651-2227.2002.tb00116.xK McFaddenK McFaddenActa Paediatrica
We investigated the presence of the gene mutation of factor V, FV ^l)6Q or factor V Leiden, responsible for activated protein C resis- nce, in DNA samples of 127 probands and 188 relatives from 128 jinhes with antithrombin deficiency.The factor V mutationwas iden- ned in 18 families. Ni...
Mechanism and pathophysiology of activated protein C-related factor V leiden in venous thrombosis Mohd,Yusuf,Ashish,... - 《Asian Journal of Transfusion Science》 被引量: 4发表: 2012年 Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. Patients ...
Individuals with a positive screening assay should have the DNA test for confirmation and to distinguish heterozygotes, homozygotes, and "pseudohomozygotes" who are heterozygous for both Factor V Leiden and a second mutation causing Factor V deficiency. When relatives of individuals known to have ...
Factor V deficiency differs from the more common factor V Leiden mutation, resulting in resistance to APC and the inability to block factor V's anticoagulant effects. Individuals with factor V Leiden mutations are thus at increased risk of venous thromboembolic events. ...
It is well documented that factor V Leiden mutation (FVL) is a common hypercoagulable risk factor in the Caucasian population. Patients with homozygous FVL mutation have an increased risk for venous thromboembolism. However, there have been few cases of heterozygous FVL mutation associated with ...
蛋白别名:Activated protein C cofactor; Coagulation factor V; coagulation factor V (proaccelerin, labile factor); coagulation factor V jinjiang A2 domain; Factor 5; factor V Leiden; Factor5; Proaccelerin, labile factor 基因别名:F5; FVL; PCCF; RPRGL1; THPH2 ...
Factor V Leiden mutation is a common genetic risk factor for venous thrombosis. It has been documented in up to 65% of patients with unexplained venous thromboembolism. This genetic mutation is now known to be the most common inherited cause of activated protein C (APC) resistance. Recently, ...
The molecular basis of type I or III Protein S deficiency has been investigated in three kindred also showing independent inheritance of factor V (FV) Leiden. A T to C transition in codon 570 (Met → Thr) was identified in the propositi and shown to segregate with protein S deficiency in...
Thrombophilia screen demonstrated the presence of protein S deficiency and Factor V Leiden as the prothrombotic factors, together with the demonstration of antiplatelet factor 4 antibodies, which confirms the diagnosis of heparin‐induced thrombocytopenia (type II). Reinstitution of warfarin at a low ...