The meaning of FACTOR V LEIDEN is a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood.
( 1999 ) A whole blood, multiplex PCR detection method for factor V Leiden and the prothrombin G20210A variant . Thrombosis and Haemostasis 81 , 464 – 465 .Keeney S, Salden A, Hay C, Cumming A. A whole blood, multiplex PCR detection method for factor V Leiden and the prothrombin G...
Double-Homozygosity for Factor V Leiden and the Prothrombin Gene G20210A Variant in a Young PatientWith Idiopathic Venous Thrombosis Blood, 94 (5) (1999), pp. 1828-1829 Google Scholar [3] G.M. Wulf, V.M. Van Deerlin, D.G. Leonard, K.A. Bauer Thrombosis in a patient with combined...
Leiden) that not only renders FVa less susceptible to the proteolytic inactivation by APC but also impairs the anticoagulant properties of FV. This G1691A point mutation inF5results in an arginine to glutamine substitution at amino acid 506, the site where APC cleaves FVa.217Thefactor V Leiden...
蛋白别名: Activated protein C cofactor; Coagulation factor V; coagulation factor V (proaccelerin, labile factor); coagulation factor V jinjiang A2 domain; Factor 5; factor V Leiden; Factor5; Proaccelerin, labile factor 基因别名: F5; FVL; PCCF; RPRGL1; THPH2 UniProt ID: (Human) P1225...
- 《Blood》 被引量: 89发表: 1998年 Social aspects of genetic testing for factor V leiden mutation in healthy individuals and their importance for daily practice To explore social aspects of asymptomatic carriership of factor V Leiden mutation (FVL) and how carriers have experienced procedure of ...
Some investigators speculate that the mild prothrombotic state conferred by the mutation could have reduced mortality from bleeding associated with childbirth or trauma in premodern times.5,18 In several studies, Factor V Leiden heterozygotes had significantly less blood loss during menses, childbirth, ...
Objectives:Carriers of the Factor V Leiden Mutation (FVL) have an inherited resistance to activated protein C (APC) proteoloysis. FVL is the main cause of thrombophilia, and FVL carriers are supposed to have lower postoperative blood loss after surgery. Aprotinin may inhibit APC. The aim of ...
clotting factor,coagulation factor- any of the factors in the blood whose actions are essential for blood coagulation Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. Want to thank TFD for its existence?Tell a friend about us, add a link to ...
ABO blood group genotypes and the risk of venous thrombosis: effect of factor V Leiden Among the 471 patients, 92 (19.5%) carried factor (F)V Leiden compared with 14 (3.0%) of the 471 controls, yielding an OR for venous thrombosis of 7.9 (95%... VM Morelli,MCHD Visser,HL Vos,......