with CD21, CD22, and the B cell receptor. CD19 polymorphisms and up‑regulation lead to the development of autoimmunity by promoting autoantibody production. Within the extracellular domain, human CD19 (Accession # P15391) shares 57% amino acid sequence identity with mouse and rat CD19. ...
The human CD19 protein, encoded by the CD19 gene located on chromosome 16p11.2, is 556 amino acids (aa) in length with a calculated theoretical molecular weight (MW) of 61 kDa and an observed molecular weight of 95 kDa (1-3). CD19 associates with other molecules - CD21, CD81, and...
天津300020；2 天津医学健康研究院；3 天津市急腹症器官损伤与中西医修复重点实验室摘要：目的 构建并表达Anti -CD19Fab -（CP ）3二聚化抗体，鉴定其蛋白分子量及相对含量并观察其靶向性。方法 通过基因克隆技术构建原核表达载体PAYZ -Anti -CD19Fab - （CP ）3及阳性对照质粒PAYZ -Anti -CD19Fab -（CPP...
(Fab)-CH3 exhibits an better targeting effect with Raji in CD19 positive B-cell lymphoma.%目的 构建针对CD19的融合蛋白anti-CD19(Fab)-CH3,并观察其靶向性.方法 采用基因克隆技术,构建基因重组质粒pAZY-anti-CD19(Fab)-CH3,测序鉴定后,转化至大肠杆菌16C9,表达产物经Protein G亲和层析柱纯化后,采用SDS-...
研究抗体毒素偶联新型药物anti—CD19(Fab)一 LDM体内外靶向CD19+B淋巴瘤细胞的能力。方法 制备 Cy5标记的anti—CD19(Fab)一LDP(LDP为LDM辅基蛋白), 体外流式细胞仪分析其与人淋巴瘤Raji细胞表面CD19抗 原的结合能力;体内建立裸鼠淋巴瘤皮下移植瘤模型,应用 ...
摘要:目的 研究抗体毒素偶联新型药物antiCD19(Fab) LDM体内外靶向CD19+B淋巴瘤细胞的能力。方法 制备 Cy5标记的antiCD19(Fab)LDP(LDP为LDM辅基蛋白), 体外流式细胞仪分析其与人淋巴瘤Raji细胞表面CD19抗 原的结合能力;体内建立裸鼠淋巴瘤皮下移植瘤模型,应用 活体动物成像系统观察Cy5标记的antiCD19(Fab)LDP在...
Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human MS4A1/CD20 PE-conjugated Monoclonal Antibody (Catalog # FAB4225P) or (B) Mouse IgG1Phycoerythrin Isotype Control (Catalog # IC002P...
PBMC lymphocytes were stained with Mouse Anti-Human CD19 PE-conjugated Monoclonal Antibody (Catalog # FAB4867P) and either (A) Mouse Anti-Human CD27/TNFRSF7 Alexa Fluor® 488-conjugated Monoclonal Antibody (Catalog # FAB382G) or (B) isotype control antibody (Catalog # IC002G). V...
Human peripheral blood mononuclear cell (PBMC) lymphocytes were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog #) and either (A) Mouse Anti-Human Siglec-6/CD327 PE-conjugated Monoclonal Antibody (Catalog # FAB2859P) or (B) Mouse Phycoerythrin Isotype Control. View...
CD19+human lymphocytes were stained with Mouse Anti-Human FCRL5/FCRL3 PE-conjugated Monoclonal Antibody (Catalog # FAB20871P, filled histogram) or isotype control antibody (Catalog #IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins. ...