检索文献和HGMD数据库(The Human Gene Mutation Database),本研究中检出的5种F10基因突变中,错义突变c.706G>A、c.1271T>C、c.G400A、c.G262A及无义突变c.1152C>A均为新突变。 5. 治疗:11例患者中,4例输注凝血酶原复合物浓缩物(PCC)治疗,7例输注新鲜冰冻血浆(FFP),患者多于PCC无法获得时选择FFP...
ObjectiveTo analyze the F10 gene mutations in a Chinese pedigree affected with the deficiency of the hereditary coagulation factor X (FX), resulting from a new deletion mutation, and to study the associated molecular pathogenesis. MethodsNext generation sequencing (NGS) was performed to screen the ...
FIOgene;F10recombinantprotein;Hydatidiformmole 0 引 言 在我们前期的研究中,为研究滋养层有节制侵 入的分子机制,选择滋养层侵袭性正常的早孕绒毛 和滋养层发育异常的完全性葡萄胎组织标本,采用 基金项目:国家自然科学基金(81170595) 作者单位:510515广东,南方医科大学南方医院妇产科[庞战军(医 ...
Interleukin (IL)-38, encoded by the IL1F10 gene, is a member of the IL-1 family of cytokines. IL-38 is constitutively expressed in epithelia in healthy humans, and in particular in epidermal keratinocytes in the skin. IL-38 expression is closely correlated with keratinocyte differentiation. ...
货号产品名称Method规格价格货期 CDS-R02985-14rLV-F10重组过表达慢病毒10^8 Tu/支￥25002-3周 CDS-R02985-15rLV-sh-F10重组干扰慢病毒10^8 Tu/支￥25002-3周 CDS-R02985-16rLV-cas9-F10重组基因编辑慢病毒10^8 Tu/支￥25002-3周 F10 ORF克隆 ...
ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on ...
HBc相互作用因子的基因注释分析(gene ontology,GO)显示,在核酸酶处理或不处理条件下与HBc显著相关的因子中,约有50%是核酸结合蛋白,属于RBP家族。在核酸酶存在的情况下,鉴定出的丰度最高的蛋白质种类(Q-value : 1.8 x10-29)与RNA转录...
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping bu...
[2]Ercolano, Giuseppe, et al. "Knockdown of PTGS2 by CRISPR/CAS9 system designates a new potential gene target for melanoma treatment." Frontiers in pharmacology 10 (2019): 1456.[3]Das, Krishna, et al. "Generation of murine tumor cell lines deficient in MHC molecule surface expression ...
[2]Ercolano, Giuseppe, et al. "Knockdown of PTGS2 by CRISPR/CAS9 system designates a new potential gene target for melanoma treatment." Frontiers in pharmacology 10 (2019): 1456. [3]Das, Krishna, et al. "Generation of murine tumor cell lines deficient in MHC molecule surface expression us...