F-box and WD-40 domain protein 7 (Fbw7) provides substrate specificity for the Skp1-Cullin1-F-box protein (SCF) ubiquitin ligase complex that targets multiple oncoproteins for degradation, including cyclin E, c-Myc, c-Jun, Notch, and mammalian target of rapamycin (mTOR). Fbw7 is a bona ...
F-box, WD-40 Domain Protein 7 (FBXW7), Isoform 2, AGO, CDC4, SEL10 (homolog of C. elegans sel-10), FBW7 FBXO30, Rabbit anti-Human, Drosophila (homolog of archipelago), ELISA中文名: 中文别名: CBNumber: CB0984649 分子式: 分子...
英文名称:F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) Polyclonal Antibody,中文名称:含蛋白7(FBXW7)多克隆抗体的F-Box和WD重复结构域,产品货号:CAU21630,[其他名称:AGO;CDC4;FBW7;FBX30;FBXW6;SEL-10;SEL10;群岛同系物;F-box和WD-40结
In normal tissues, numerous proteins encoded by proto-oncoproteins are degraded by ubiquitylation enzymes, consisting of F-box/WD-40 repeat-containing protein 7 (Fbw7) and other proteins, thus avoiding tumorigenesis and maintaining homeostasis. In tumor tissues, the downregulation of Fbw7, caused by ...
PAJ890Mu01, AGO; CDC4; FBW7; FBX30; FBXW6; SEL-10; SEL10; Archipelago Homolog; F-box and WD-40 domain-containing protein 7 | Products for research use only!
Furthermore, miR-25 repressed F-box and WD-40 domain protein 7 (FBXW7) expression by directly binding to 3-untranslated region (UTR) of FBXW7, and the inverse correlation was observed between the expressions of miR-25 and FBXW7 mRNA in primary GC tissues. Moreover, the restoration of ...
5188 The FBXW7 (F-box and WD40 domain protein 7) was mapped to human chromosomal region 4q31, one of the major loci for familial pancreatic cancer, and frequent deletion of this locus was reported in a wide range of human tumor types. ... Z Gu,K Inomata,H Mitsui,... - 《Cancer...
产品名称:F-box蛋白家族FBXO7抗体 英文名称:FBXO7 别称:F box only protein 7; F box protein 7; F-box protein 7; FBX; FBX07; FBX7; PARK15; PKPS; 产品介绍: FBXO7,也称为FBX,FBX7或PKPS,是一种522个氨基酸的蛋白质,包含一个F-box结构域,并作为SCF复合体的成分起作用。编码FBXO7的基因缺陷...
According to its protein C-terminal domain,F-box genes are divided into different subfamilies,for its number is large. Proteins encoded by F-box gene can regulate a variety of life activities,such as delaying plant senescence,regulating plant flowering and response to biological stress,drought and...
F-box蛋白根据C端的不同可分为3类:①富含亮氨酸重复序列(LRRs)的称为FBXL(F-box and leucine-rich repeat protein);②富含WD(Trp-Asp)重复序列的为FBXW(F-box and WD repeat domaincontaining protein);③富含其他二级结构,如钙调蛋白同源体、亮氨酸拉链、锌指结构、环指结构或者无明显结构特点等,称为FBXO...