F-box proteinchemoresistancecancerSKP2FBXW7The ubiquitin proteasome system (UPS) regulated human biological processes through the appropriate and efficient proteolysis of cellular proteins. F-box proteins are the vital components of SKP1-CUL1-FBP (SCF)-type E3 ubiquitin ligases that determine substrate...
Díaz VM, de Herreros AG (2016) F-box proteins: keeping the epithelial-to-mesenchymal transition (EMT) in check. Semin Cancer Biol 36:71–79 Heo J, Eki R, Abbas T (2016) Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis. Semin Cancer Bi...
Here, we explore the functionality and biology of the F-box proteins, SKP2 (S-phase kinase-associated protein 2) and β-TrCP (β-transducin repeat-containing protein), which are emerging as important players in cancer biogenesis owing to the deregulated proteolysis of their substrates. This is...
图1 F-Box蛋白家族在病毒-宿主相互作用中发挥的功能 Figure 1 Functions of FBPs in virus-host interactions The FBPs exhibit diverse functional roles in virus-host interactions based on their specific targets. FBPs can exert antiviral effects by degrading viral proteins and activating interferon signalin...
Proteins encoded by F-box gene can regulate a variety of life activities,such as delaying plant senescence,regulating plant flowering and response to biological stress,drought and salt stress. In recent years,with the improvement of whole genome sequencing,more and more F-box genes of different ...
生命活动中具有广泛而重要的作用,并指出了F-box蛋白将为阐明疾病发生机制提供新的线索,可望成 为疾病治疗中药物作用的靶向位点。 关键词:F-box蛋白;泛素-蛋白酶体途径;SCF复合体 中图分类号:Q51 文献标识码:A F-boxproteinsandtheirfunctions WANGXiu-yan 1 ,SUNLi-ping 1 *,ZHANGJian-feng 1 ,LIHui 1 ,...
3Cancer Research Center, Xiamen University, Xiamen 361005, China) Abstract: F-box proteins are an expanding family of eukaryotic proteins characterized by an “F-box” motif. They are in charge of substrate specificity in the ubiquitin-proteasome pathway and therefore play a pivotal role in many...
SCF components have recently attracted significant attention on cancer therapeutic drug development and potential to modulate inflammation and innate immunity.9,12 F-box proteins contain two domains: an NH2-terminal F-box motif and a carboxyl terminal leucine-rich repeat (LRR) motif or tryptophan-aspa...
目前对于F-box的认识还很匮乏,随着生殖医学领域的不断发展,需要更多研究来揭示其他F-box家族成员调控卵巢功能的机制及其在卵巢疾病发生中的作用。 参考文献 【相关文献】 [1] Skaar JR,D′Angiolella V,Pagan JK,et al.SnapShot:F Box Proteins II[J].Cell,2009,137(7):1358.e1. [2] Cardozo T,Pagano...
of F-box proteins in biological processes and environmental adaptation. This review presents a background of E3 ligases with particular emphasis on the F-box proteins, their structural assembly, and their mechanism of action during substrate recognition. We discuss how the F-box proteins regulate an...