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In using this method, we assume that while the network is not contractile on average during the study (hεi ∼ 0), that changes in the fluctuation in time, or the increase in the RMS value of ε (Supplementary Fig. 6) does not significantly impact our correlation. For mDia1-nucleated...
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Embedding the BCL11A shRNAs into a miRNA architecture to facilitate pol II-directed expression was associated with less toxicity but uniformly decreased knockdown efficiency due to miRNA processing that resulted in alternate guide strands. Thus, we designed shRNAmiRs that mimicked the mature guide ...
2). By using the ensemble to calculate velocity models, we allowed the data to guide the choice of where layers are required rather than prescribing them a priori. The final model was then calculated by using the ensemble model as input to a final run of VELEST. This ensured that our ...
Although some studies have examined the relationship between lung function and post-esophagectomy P PCs5,16–18, these are limited by their study design (single center with a single surgeon), patient enrollments in the past, small numbers of participants, reliance on multiple imputation due ...
In this study, as exemplified by tissue from one GBM patient, we present that whole slices can be recorded and analyzed automatically (Fig. 6). Therefore, it is possible to retrospectively draw conclusions about the extent of heterogeneity in the original tissue. The automation of the ...
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In the 1980s, the scientific community recognized the close coupling of these disciplines and began to study them as interacting elements of a single system. During this second phase, the paradigm of Earth system science emerged. With it came the ability to understand complex, system-oriented ...