ezetimibe,atorvastatin calcium tablets 药品简介 依折麦布阿托伐他汀钙片主要用于原发性高脂血症。本品能够降低原发性(杂合子家族及非家族) 或混合型高脂血症患者体内已升高的总胆固醇(总-c)、低密度脂蛋白胆固醇 (ldl-c)、载脂蛋白b(apo b)、甘油三酯(tg)、非高密度脂蛋白胆固醇(non-hdl-c) 的水平,并...
AtorvastatinLactate DehydrogenaseMyopathyEzetimibeThis article presents information on the medical case of a 42-year-old man who developed rhabdomyolysis while concomitantly being treated with atorvastatis, ezetimibe and phenytoin. It explains that the patient presented to doctors complaining of intense pain...
Atorvastatin: Inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme which is responsible for catalyzing an early step in the synthesis of cholesterol. Ezetimibe: Inhibits absorption of cholesterol in the small intestine. Therapeutic Effect(s): Lowering of lipids with decrease...
Protein Binding:Atorvastatin:≥98%. Metabolism and Excretion:Atorvastatin:extensively metabolized by the liver, most during first pass; excreted in bile and feces. <2% excreted unchanged by the kidneys. 2 metabolites have lipid-lowering activity.Ezetimibe:undergoes enterhepatic recycling, mostly eliminated...
在ezetimide与atorvastatin和辛伐他汀联合使用的I期实验中,ezetimibe使LDL降低的程度增加了18%,与单纯ezetimibe疗法的研究结果相似。 一位公司发言人对记者说,III期实验联合研究结果将在今年晚些时候公布。他拒绝说明这种新药会在什么时候获准上市。 法国第戎Point Medical 的Michel Farnier教授说:“在高脂血症治疗方法...
* Patients receiving each statin: 40% atorvastatin, 31% simvastatin, 29% others (pravastatin, fluvastatin, cerivastatin, lovastatin). †Baseline - on a statin alone. ‡Ezetimibe + statin significantly reduced total-C, LDL-C, Apo B, and non-HDL-C compared to statin alone. Treatment (Dail...
Use in combination with atorvastatin or simvastatin to decrease elevated serum total and LDL-cholesterol concentrations in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies (e.g., plasma LDL apheresis) or when such therapies are not available. ...
However, adverse effects in a few patients with an increase of creatine kinase activity and myopathy after combination therapy of ezetimibe with atorvastatin have been described recently (Fux et al., 2004). Control of ezetimibe pharmacokinetics and potential pharmacological interactions could involve the...
(atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin), fibric acid derivatives (gemfibrozil, fenofibrate), digoxin, glipizide, warfarin and triphasic oral contraceptives (ethinylestradiol and levonorgestrel). Concomitant administration of food, antacids, cimetidine or ...
in very low amounts in milk and serum levels in infants predicted by a pharmacokinetic model are considerably lower than in adults. Ezetimibe appears to be acceptable during breastfeeding. Ezetimibe in combination with a statin (e.g., atorvastatin, simvastatin) should be avoided in nursing ...