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ve B cells.Then we manipulated the expression of EZH1 and EZH2 in MCL cells using CRISPR/Cas9 system to directly investigate their functional roles in MCL.We also evaluated the effect of two small molecule selective inhibitors, EPZ005687 and UNC1999, on MCL cell proliferation, cell cycle ...
Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest. Cell Stem Cell, 11(5): 649–662Hidalgo I, Herrera-Merchan A, Ligos JM, Carramolino L, Nunez J, Martinez F, Dominguez O, Torres M, Gonzalez S. Ezh1 is required for hematopoietic stem...
The article concentrates on the issues of the cycle of illustrations by Elwiro Micha Andriolli inEliza Orzeszkowa's Meir Ezofowicz as a work of art of the second half of the 19th century, anexcellent inter-semiotic translation of literature into the "image rhetoric", and an example of a...
CELL cycleCELL proliferationB cellsSMALL moleculesObjective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in MCL and the underlying mechanisms.Methods: In this study, we elucidated the role of EZH1 and EZH2 overexpression by immunohistochemistry and...
EZH1/2Acute lymphoblastic leukemiaCell cycle arrestCDKN1CTP53INP1International Journal of Hematology - Disease-risk stratification and development of intensified chemotherapy protocols have substantially improved the outcome of acute lymphoblastic leukemia......
ve B cells.Then we manipulated the expression of EZH1 and EZH2 in MCL cells using CRISPR/Cas9 system to directly investigate their functional roles in MCL.We also evaluated the effect of two small molecule selective inhibitors, EPZ005687 and UNC1999, on MCL cell proliferation, cell cycle ...
Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57(CDKN1C) and TP53INP1 in mantle cell lymphomaMantle cell lymphomaEZH1EZH2CRISPR/Cas9Objective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in ...