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Objective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in MCL and the underlying mechanisms.Methods: In this study, we elucidated the role of EZH1 and EZH2 overexpression by immunohistochemistry and correlated them to clinical outcome in 41 MCL...
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ROMERO, ELENA
ve B cells.Then we manipulated the expression of EZH1 and EZH2 in MCL cells using CRISPR/Cas9 system to directly investigate their functional roles in MCL.We also evaluated the effect of two small molecule selective inhibitors, EPZ005687 and UNC1999, on MCL cell proliferation, cell cycle ...
Ezh1 is required for hematopoietic stem cell maintenance and pre- vents senescence-like cell cycle arrest. Cell Stem Cell 2012;11:649e62.Hidalgo I, Herrera-Merchan A, Ligos J M, Carramolino L, Nunez J, Martinez F, Dominguez O, Torres M, Gonzalez S (2012). Ezh1 is required for ...
Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57(CDKN1C) and TP53INP1 in mantle cell lymphomaMantle cell lymphomaEZH1EZH2CRISPR/Cas9Objective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in ...
Annual developmental cycle of gonads of European perch females (Perca fluviatilis L.) from natural sites and a canal car- rying post-cooling water from the Dolna Odra Power Plant (NW Poland). Folia Biologica-Krakow 63: 85-93.Kirczuk, L.; Domagała, J.; Pilecka-Rapacz, M. Annual ...
The rudd is a common freshwater species of the European ichthyofauna, however, this species' sexual cycle has not yet been described based on the histological analysis of its gonads. The aim of this study was to analyze the annual gonad development cycle of rudd from the watercourses of north...