N. ( 2002 ) The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injury . Neuroscience 114 , 755 – 767 .Dash P, Mach S, Moore A. The role of extracellular signal-regulat- ed kinase in cognitive and motor deficits following ...
M Rezaee,K Isokawa,N Halligan,... - 《Journal of Biological Chemistry》 被引量: 162发表: 1993年 Identification of novel extracellular signal-regulated kinase docking domain inhibitors. The signal regulated kinase (and ) signal pathways play a critical role in . Hyperactivation of the proteins ei...
On the other hand, the downstream components ERK (extracellular signal-regulated kinase) showed a declined expression tendency accompanied by enhanced phosphorylated ERK1/2 (p-ERK), which results in an increased ratio of p-ERK/ERK (Fig. 3D–G). In addition, we performed immunostaining to ...
et al. Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration. Cancer Res. 64, 1044–1049 (2004). 16. Itoh, Y. MT1-MMP: A key regulator of cell migration in tissue. IUBMB Life 58, 589–...
A. & Raab-Traub, N. Epstein–Barr virus latent membrane protein 2 induces autophagy to promote abnormal acinus formation. J. Virol. 89, 6940–6944 (2015). Article CAS PubMed PubMed Central Google Scholar Inoue, J. et al. HBV secretion is regulated through the activation of endocytic and...
A. & Raab-Traub, N. Epstein–Barr virus latent membrane protein 2 induces autophagy to promote abnormal acinus formation. J. Virol. 89, 6940–6944 (2015). Article CAS PubMed PubMed Central Google Scholar Inoue, J. et al. HBV secretion is regulated through the activation of endocytic and...
In A549 cells, the eukaryotic translation initiation factor kinase 4 (EIF2AK4) pathway was suppressed by S2 EVs, but upregulated by S3 and S4 EVs (Fig. 5f). Response of EIF2AK4 (GCN2) to amino acid deficiency was also among the top altered pathways after SARS-CoV-2 infection of ...
In addition, a recent work showed that a novel candidate receptor, the tyrosine-protein kinase receptor UFO (AXL), specifically interacted with SARS-CoV-2 S protein and promoted viral entry as efficiently as hACE-2 overexpression via “apoptotic mimicry”. Downregulating AXL was found to reduce ...
Interestingly, DCN and LUM were strongly upregulated, on mRNA and protein levels, in floating spheroid cultures of SK-N-SH NB cells grown in serum-free (SF) neural stem cell medium to allow for enrichment of population of cancer stem cell-like cells (CSCLC), as compared with adherent ...
Macrophages can also be regulated by neuron- or SC-derived EVs; (c) Innervated (target) tissue/cell-derived EVs can participate in intercellular crosstalk with neurons, axons, and SCs. In the case of cancer, under innervation, the tumor (target tissue) is involved in intercellular crosstalk ...