GO analysis revealed significant enrichment of EP-DEGs in BP (e.g., extracellular matrix organization), CC (e.g., collagen-containing extracellular matrix), and MF (e.g., extracellular matrix structural constituent) (Fig. 3A, Supplementary Data S4). Concurrently, KEGG analysis indicated that EP...
Microfibrils, 8–12 nm in diameter, are one constituent of elastic fibres (see Fig. 4.9). They are also found in the extracellular matrix of renal glomeruli (mesangium) and the suspensory fibres of the lens. Microfibrils are prominent in elastic-containing extracellular matrix, particularly...
associations with terms such as secretory granule lumen, cytoplasmic vesicle lumen, focal adhesion, vesicle lumen, blood microparticle, wound healing, blood coagulation, coagulation, humoral immune response, hemostasis, cadherin binding, integrin binding, and extracellular matrix structural constituent (Fig....
most microtubules are not anchored to the centrosome. Instead, their minus-ends are stabilized by binding to a family of proteins, including calmodulin-regulated spectrin-associated proteins (CAMPSAPs)79, that were identified in the GO termstructural constituent(GO:0005201). Interestingly, the...
Three terms of MF had notably lower qvalues: calcium ion binding, ECM structural constituent and microtubule binding (Fig. 2e). However, the 114 enriched terms from the upregulated DEGs were in contrast mainly connected to synaptic transmission, synaptic membranes, and ion channels. In BP, ...
Another major structural entity particularly important in the anulus is the network of collagen fibers; fibril-forming collagen 1 is a major constituent. The collagen fibrils in the anulus are largely oriented in sheets around the nucleus. A number of molecules present in the matrix regulate and ...
In the “Molecular Function” category, proteins mainly accounted for Extracellular matrix structural constituent (GO: 0005201, 10/66), Heparin binding (GO: 0008201, 11/66), Calcium ion binding (GO: 0005509, 17/66), Extracellular matrix binding (GO: 0050840, 5/66), Hyaluronic acid binding (...
1) spatio-temporal specific expression of the classically described constituents, 2) the finding of laminin and collagen IV variants, 3) changes in the ratio of individual constituent chains, and 4) a stage-specific regulation of basement membrane molecule production, in particular by glucocorticoids...
The constituent materials within the interstitium can vary widely. Animal ECM contains protein, minerals, and fiber. The extracellular matrix of plants is constructed from cellulose. ECM provides the essential physical scaffolding for our seventy trillion internal cells to roam and thrive. It is a dy...
They are mainly enriched in extracellular exosomes, involved in extracellular matrix structural constituent, and associated with extracellular matrix-receptor interaction pathway. This study also indicated that human plasma contains more EVs than the paired serum at the same volume, and showed age- and ...