(https://string-db.org), according to the classification of each protein B) extracellular matrix structural constituent (GO: 0005201); C) related to cell migration (GO:0016477); D) related to cellular differentiation (GO:0030154) and E) PI3K-Akt signaling pathway (KEGG pathways-hsa04151). ...
Fibrillin is a fibril-forming glycoprotein and the main component of extracellular microfibrils. Microfibrils, 8–12 nm in diameter, are one constituent of elastic fibres (seeFig. 4.9). They are also found in theextracellular matrixof renal glomeruli (mesangium) and the suspensory fibres of...
The ECM is a key constituent of the vascular wall. SMCs and the FBs in the aortic wall synthesize and organize a complex ECM structure that defines the passive mechanical behavior of the large, elastic arteries such as the aorta. Arterial ECM is primarily composed of elastin, collagen, proteog...
we evaluated the effects of 1 × 109particles/ml CPCs-EVs on cartilage matrix homeostasis in IL-1β-induced chondrocytes. First, the cartilage matrix GAG and collagen contents were detected in IL-1β-induced chondrocytes after CPCs
being permissive to axon growth and plasticity [10]. Synthesis of GAGs and their sulphation occurs in the Golgi, sulphation being determined by the activity of sulfotransferases that sulphate CS and HS chains in various positions on the constituent disaccharides [11]. In addition to being a ...
we focused on the specific patterns of 4T1/Tn+by comparing 4T1/Tn+versus 4T1/wt and 4T1/Tn+versus 4T1/Tn−. The GO enrichment analysis showed that functional terms such asextracellular matrix(ECM)structural constituent(GO:0005201),cell junction(GO:0030054),metallopeptidase activity(GO:0008237...
Extracellular Matrix News February 5, 2025 [Nature] Scientists used two mouse models of pulmonary fibrosis to show that LEPR+fibroblasts that arise during alveologenesis included SCUBE2+alveolar fibroblasts as a major constituent. These alveolar fibroblasts in turn contributed to pathological fibroblasts....
Another major structural entity particularly important in the anulus is the network of collagen fibers; fibril-forming collagen 1 is a major constituent. The collagen fibrils in the anulus are largely oriented in sheets around the nucleus. A number of molecules present in the matrix regulate and ...
Extracellular matrix (ECM) is an important structural and functional constituent of both healthy and diseased blood vessels. Vascular cells are embedded in the multicomponent network of the ECM that contains collagens, other glycoproteins, proteoglycans and carbohydrates. The interaction between embedded ...
Three terms of MF had notably lower qvalues: calcium ion binding, ECM structural constituent and microtubule binding (Fig. 2e). However, the 114 enriched terms from the upregulated DEGs were in contrast mainly connected to synaptic transmission, synaptic membranes, and ion channels. In BP, ...