binding proteinHyaluronate receptorTenascinVersicanHyaluronic acid (HA) plays the main structural role in the formation of brain extracellular matrix (ECM). The extracellular space appears empty by electron microscopy because HA is readily dissolved during the preparation of tissues for ultrastructural ...
Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: Comparison between invasive and non‐invasive areas We performed quantitative determination of the distribution of hyaluronan (hyaluronic acid, HA) and the HA-binding protein, hyaluronectin (HN), 2 ...
Among all the components of ECM, hyaluronic acid (HA) is undoubtedly one of the most abundant. Although being part of the GAG family, HA is the only one which is not bound to a PG core protein [8]: it is a linear GAG composed of repeating disaccharide units of D-glucuronic acid (Gl...
IHC staining of renal tissues confirmed significantly elevated TNF-a expression and decreased hyaluronic acid (HA) levels in the DN group compared to controls (both P < 0.05), with a negative correlation observed between TNF-a and HA (r = − 0.691, P = 0.026). Conclusion...
et al. The extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-type Ca(2+) channels. Neuron 67, 116–128 (2010). CAS PubMed PubMed Central Google Scholar Massey, P. V. et al. Learning-specific changes in long-term depression in...
Cells exist within a structural framework, the extracellular matrix (Box 4-6), which is secreted by the cells such as the myofibroblast during wound healing and consists of several classes of macromolecules, the most abundant of which is collagen (accounting for 30% of total protein in the org...
The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are als...
1、细胞外基质(II)定义概述(Extracellular matrix, ECM) (二) 非胶原糖蛋白(non-collagenous glycoprotein) 非胶原糖蛋白由多个结构域构成的多功能的大分子既可与细胞相结合,又可与细胞外基质其它大分子相结合,介导细胞与细胞外基质其他成分的粘着是必要的结构成分,而且也是实现细胞外基质生物学作用的重要成分 。
Several extracellular matrix (ECM) components, such as Reelin, integrin ligands, tenascin C and hyaluronic acid, regulate induction of synaptic plasticity through their modulatory effects on NMDA (N-methyl-D-aspartate) receptors and L-type voltage-dependent Ca2+channels, which are the major players ...
Nrf2 is a leucine zipper protein that regulates the expression of antioxidant proteins and is considered a protective mechanism in the pathogenesis of pulmonary fibrosis, although this requires formal proof [133]. Interestingly, hyaluronic acid upregulates the expression of Nrf2 in chondrocytes via Akt...