show how dynamic changes in attractive and repulsive interactions between cells and various matrix components drive biofilm growth and disassembly in Vibrio cholerae. Alexis Moreau Danh T. Nguyen Jing Yan ResearchOpen Access02 Jan 2025 Nature Communications Volume: 16, P: 327 Ezrin drives ...
In addition, fibroblasts maintain ECM and participate in ECM turnover by secretion of proteases, most notably members of the matrix metalloproteinase (MMP) family, that degrade the various molecular components [4]. In fact, the ECM is continually being remodeled, either enzymatically or non-...
obese mice remained intact. Unlike insulin signalling, enzymatic disassembly of the ARC PNN did not restore leptin sensitivity in the ARC, indicating that neurofibrosis does not regulate leptin entry and signalling (Extended Data Fig.5r–x). To understand how neurofibrosis affects insulin infiltration...
Cells respond to mechanical stress by rapid disassembly of caveolae. Cell 144, 402–413 (2011). Article CAS Google Scholar Wong, S. W., Lenzini, S., Cooper, M. H., Mooney, D. J. & Shin, J. W. Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells ...
Extracellular matrix EGFR: Epidermal growth factor receptor ERK: Extracellular signal regulated kinase ESCRT: Endosomal Sorting Complex Required for Transport EV: Extracellular vesicle GAP: GTPase activating protein GDI: GDP dissociation inhibitor GEF: Guanine nucleotide exchange factor GPCR: G ...
Apical extracellular matrix (aECM) constitutes the interface between every tissue and the outside world. It is patterned into diverse tissue-specific structures through unknown mechanisms. Here, we show that a male-specific genetic switch in a single C. elegans glial cell patterns the overlying aECM...
A schematic representation of the role of extracellular vesicles as mediators of intercellular crosstalk in the tumor microenvironment influencing several biological mechanisms. Abbreviations: ECM, extracellular matrix; MMP, matrix metalloproteinase; uPA, urokinase plasminogen activator; MV, microvesicle; ROS, ...
Besides the two major and well-studied categories, EVs could be released through other cellular processes with different average sizes. For example, disassembly of apoptotic cells gives rise to the apoptotic body with a diameter of 800–5000 nm, which contains components and information from the dy...
The extracellular matrix protein agrin promotes heart regeneration in mice. Nature 547, 179-184. http://dx.doi.org/ 10.1038/nature22978.Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch- Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Bassat DR, Udi Y, Sarig R, Sagi I,...
(see also Ref.85). Besides genes involved in the circulatory system development and extracellular matrix/cell motility (see “Gene set enrichment analysis” section below) we identified two differentially expressed genes of interest. The first,DIO2, is involved in sensitive periods66,67and in the...