Cells respond to physical stimuli, such as stiffness1, fluid shear stress2and hydraulic pressure3,4. Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such as cancer5. However, its influence on cancer biology and the mechanism by which ...
Cells respond to physical stimuli, such as stiffness1, fluid shear stress2and hydraulic pressure3,4. Extracellular fluid viscosity is a key physical cue that varies under physiological and pathological conditions, such as cancer5. However, its influence on cancer biology and the mechanism by which ...
Gene therapies and cellular programming rely on effective cell transfection. Despite continuous advancements in carrier development and transfection techniques to enhance efficiency, the biophysical parameter of extracellular fluid viscosity has been largely overlooked. Here we report a substantial impact of ...
Cell and tissue active sodium and so-called osmotically inactive sodium Chloride storage in the skin was first reported more than 100 years ago,20 and found its way into the textbooks as a homeostatic-regulatory principle of body fluid homeostasis.21 We do not know how, why, and when in the...
As a signaling molecule, HA can promote cell adhesion, migration, and proliferation [104]. Additionally, its water-soluble nature and high viscosity make it a suitable material for bioprinting, often employed to modulate the viscosity of other biomaterial solutions [105, 106]. However, native HA...
Insertion of amphipathic molecules into the lipid bilayer of exosomes Enhances target cell uptake; improves therapeutic efficiency; can cross the blood-brain barrier Complex modification process; may change the native structure of exosomes; need to optimize the insertion and stability of different molecule...
Extracellular vesicles have shown promising tissue recovery-promoting effects, making them increasingly sought-after for their therapeutic potential in wound treatment. However, traditional extracellular vesicle applications suffer from limitations such
Extracellular fluid viscosity has been shown to affect cell-substrate adhesion and mechanosensing17. Thus, we evaluated whether SK-HEP-1 cells responded to a 1% Na-alginate solution when adhered to compliant in vivo-like substrates. Collagen-functionalised polyacrylamide (Col-PAA) gels were used as...
(e.g., blood, saliva, urine, nasal secretion, breast milk, cerebral spinal fluid (CSF), cultured cell-conditioned medium), and sometimes biological fluids can be diluted by PBS with an equal volume based on its viscosity, which can improve the recovery of EVs [42]. According to their ...
In electrospinning, a phenomenon known as the ‘Taylor cone’ emerges in the droplet, and deforms the equilibrium where the droplet’s surface tension and the fluid’s viscosity offset the applied tensile force. This formation initiates the ejection of a fine polymer solution from the cone's ...