EXT1 is expressed in the brain, and both EXT1 and EXT2 proteins are associated with glycosyltransferase activities required for the biosynthesis of heparan sulfate, which also has activity in the brain. The coincidental association of mental disorders in the boys was not completely excluded. ...
EXT1 is expressed in the brain, and both EXT1 and EXT2 proteins are associated with glycosyltransferase activities required for the biosynthesis of heparan sulfate, which also has activity in the brain. The coincidental association of mental disorders in the boys was not completely excluded. ...
brain Quick-clone cDNA library (Clontech) using the following primers for EXT1: sense primer, 5′-CTCTTGACCCAGGCAGGAC-3′, and antisense primer, 5′-GGCTTCCTCAAAGTCGTTCA-3′; and for EXT2: sense primer, 5′-GAGGACGAGGACACCTGTTT-3′, and antisense primer, 5′-GGGAGGTGCGGCAAGC-3′...
These genes were the most expressed ones in the para-tumourous brain tissues and their expression levels were significantly decreased in gliomas, depending on the tumour grade. In Grade II-III tumours, there was a 4-fold decrease in the EXT1 expression level, though the EXT2 expression was ...