Expression quantitative trait loci (eQTLs) are genomic loci that explain all or a fraction of variation in expression levels of mRNAs. 基因组位点,解释了基因表达的变化。 A quantitative trait locus (QTL) is a section of DNA (the locus) which correlates with variation in a phenotype (the quantit...
Expression quantitative trait locus analysis for translational medicine. Genome medicine. 2015;7(1):60.Gibson G, Powell JE, Marigorta UM (2015) Expression quantitative trait locus analysis for translational medicine. Genome Med 7(1):60. doi:10.1186/s13073-015-0186-7...
Quantitative Trait Locus (QTL) Analysis- 来自nature的介绍 实现层面,其实研究的不是基因,而是染色体上的区段,更明确的说就是分子标记,SNP最流行,大学里还学过很多烦人的分子标记。 关联是关键,association,基本假设就是遗传片段会跟表型一起分离。 通常极少数的loci具有很高的effect size。 选择足够纯的亲代(需要...
Expression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine. Here we review how expression quantitative trait locus analysis is aiding the identificati...
Expression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine. Here we review how expression quantitative trait locus analysis is aiding the identificati...
Quantitative Trait Locus (QTL) Analysis- 来自nature的介绍 实现层面,其实研究的不是基因,而是染色体上的区段,更明确的说就是分子标记,SNP最流行,大学里还学过很多烦人的分子标记。 关联是关键,association,基本假设就是遗传片段会跟表型一起分离。 通常极少数的loci具有很高的effect size。
Identification of therapeutic targets from genome-wide association studies (GWAS) requires insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing samples from 14 brain datasets to create the MetaBrain resource and performedcis- andtrans-expression quantitative trait locus (eQTL...
Anexpression quantitative trait locus(eQTL) is a basic statistic used in the combined analysis ofGWASdata and whole-genome transcriptional results, and can be applied to identify the gene number in trait-associated areas of the genome.19PrediXcan is a commonly used statistical method that can integ...
Zhang et al.8identified a methylation quantitative trait locus. This mQTL significantly impacted expression of these genes within the genomic region of thealcohol dehydrogenasegenesADH1BandADH1C. Altered expression of ADH1B and ADH1C was in part related to alcohol dependence. ...
To address this gap in knowledge, we performed an unbiased genome-wide expression quantitative trait locus (eQTL) mapping study to identify common regulatory (expression) single nucleotide polymorphisms (eSNPs) in mid-secretory endometrium. We identified 423 cis-eQTLs for 132 genes that were ...