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Since ATRA can restore PU.1 expression in APL cells and can also induce TRAIL expression, and combination therapies with TRAIL and ATRA might be of interest.5,42 Alternatively, the use of NF-κB inhibitors in combination with TRAIL may represent an intriguing treatment option. These inhibitors ...
This multiple linear regression was conducted on the entire sample set as well as the subset of males separately in JMP. RESULTS Statin-responsive LCL genes Using RNA-seq data from 100 Caucasian and 50 African-American control- and statin-exposed LCLs derived from CAP participants, we found ...
We focused on V155M, which is a gain-of-function mutation that leads to the constitutive activation of STING1 and subsequent immune-mediated inflammatory disease in humans (Jeremiah et al., 2014; Liu et al., 2014). Compared to wild-type cells, V155M-THP1 cells had an increased basic ...
Bacteriocins produced by lactic acid bacteria (LAB) attract considerable interest as natural and nontoxic food preservatives and as therapeutics whereas the bacteriocin-producing LAB are considered potential probiotics for food, human and veterinary applications, and in the animal production field. Within ...
Stained gels were scanned with Image Scanner (GE Healthcare) and IMP7 (GE Healthcare) was used for spot analysis and the proteins of interest were marked for excision. The gel plugs were transferred directly to 1 ml Eppendorf tubes. In-gel digestion with trypsin (Promega) was done to ...
[58]. Germ cells were identified morphologically as early as cydippid stages in three clusters, two male and one female, in the meridional canal primordia on each side of the cydippid. In later stages, the middle cluster, the female germ cells, splits and becomes divided by the ...
Three of the β subunits are responsible for the proteolytic activity of the proteasome. These subunits are replaced under conditions of increased immune response or oxidative stress, resulting in the immunoproteasome (IP). (b) Proteolytic activity of the 20S CP can be regulated by three main ...
On top of the temporal analysis, two brain areas known to be involved in memory formation (hippocampal CA1 region) and memory maintenance (anterior cingulate cortex, ACC) were investigated13,14. From the CA1 and ACC we then extracted nuclei and sorted them into neuronal (NEU) and non-...
g, Apoptosis assay in MOLM13 and MV4;11 cell lines testing the impact of sgRNAs targeting Luciferase (NT control) versus two sgRNAs targeting IKZF1 on the response to MENIN inhibition with VTP-50469, using doses indicated. Apoptosis was assessed by DAPI exclusion (viability) and annexin V...