Antimicrobial peptides (AMPs) kill microbes or inhibit their growth and are promising next-generation antibiotics. Harnessing their full potential as antimicrobial agents will require methods for cost-effective large-scale production and purification. He
The nonviral method uses a nonlytic plasmid to transfect the gene of interest into the insect cells instead of using baculovirus, a lytic system. In this chapter, we describe one of the transfection methods, which uses polyethyleneimine (PEI) as a DNA delivery material into the insect cells ...
Here, we identify PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. We characterize SPOC as a CTD reader domain that preferentially binds two phosphorylated Serine-2 marks in adjacent CTD repeats. PHF3 drives ...
Neural evidence of face processing in social anxiety disorder: A systematic review with meta-analysis Neuroscience & Biobehavioral Reviews Journal 2023,Neuroscience & Biobehavioral Reviews GuanxiongPei, ...JiaJin 2.5.5Facial expression Thefacial expressiondata were extracted from the original description. ...
a Manhattan plot of all analysed CpG sites for DNA methylation in myoblasts from women versus men. The blue line indicates the threshold for significance (q < 0.05). Green dots indicated with arrows are selected CpG sites for some genes of interest. Manhattan plot with black points are CpG...
SARS-VLPs generated by the method of the present invention are highly immunogenic and can elicit not only humoral but also cellular immune responses in a mammal. Inventors: Hsiao, Pei-wen (Taipei, TW) Yang, Ning-sun (Taipei, TW) Huang, Chang-jen (Taipei City, TW) Lin, En-hau (...
Pei, T. Wei Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter Mol Biol Rep, 34 (2007), pp. 225-231 CrossrefView in ScopusGoogle Scholar 34 R.W. Johnstone Histone-deacetylase inhibitors: novel drugs for the treatment of cancer Nat Rev Drug Discov, 1 (2002), pp. ...
Comb-shaped polymer grafted with REDV peptide, PEG and PEI as targeting gene carrier for selective transfection of human endothelial cells If plasmid complexes prepared from targeting carriers have endothelial cell selectivity and high transfection efficiency, they can specifically enhance rapid endothelializa...
Adeno-associated virus (AAV) based vectors are attracting substantial interest for gene therapy to correct or supplement defective genes and to deliver therapeutics, such as antibodies, that improve disease phenotypes1,2,3. Recombinant AAV (rAAV) vectors have been administered in over 300 clinical ...
a deeper understanding of the molecular consequences of constitutive ALK signaling and its relationship to MYCN activity in this aggressive pediatric tumor entity will be essential. We show that mutant ALK downregulates the‘HMG-box transcription factor 1’(HBP1) through the PI3K-AKT–FOXO3a signaling...