In bird species with female heterogamety (ZW system), sexual dimorphism and male-targeted sexual selection79,80 led to the excess accumulation of male fitness mutations on the Z chromosome, promoting a faster evolutionary rate for the Z chromosome, which is known as the ‘fast-Z’ effect81,...
Many pathophysiological mechanisms in human health and disease are dependent on sex. Systems biology approaches are successfully used to decipher human disease etiology, yet the effect of sex on gene network biology is mostly unknown. To address this, we
On the other hand, Kim et al. (2014) predicted that the methylation has an insignificant effect on the LPMO catalytic activity based on quantum-mechanical modeling. Recently, Petrović et al. (2018) reported the functional comparison of the methylated and non-methylated variants of TaAA9A ...
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has cytoprotective effects on various injuries, including cerebral ischemia, and it can promote recovery even when delivered intracranially several days after ischemic stroke. In the uninjured rodent brain, MANF protein is expressed almost exclusive...
Because no specific stem cell population has been shown to be optimal, we investigated whether the benefit of stem cell transplantation could be attributed to a trophic effect on injured myocardium. Mesenchymal stem cells secrete SDF-1 and the interaction of SDF-1 with its receptor, CXCR4, ...
Ovarian maturation in shrimp is reliant on successful vitellogenesis, which is known to be mediated by an eyestalk peptide hormone GIH. Eyestalk ablation destroys the synthesis and storage site of GIH, and thus is a powerful technique that has been widely used in the hatcheries to induce ovaria...
1. Introduction The Ising model [1,2] is a simple but at the same time very powerful model. Originally developed to describe ferromagnetism, the Ising model has evolved to be one of the most important theoretical models in physics since it was first described 100 years ago. The applications...
(TLR3-mt). At 48 h after transfection, we performed dual-luciferase reporter assays on DEF cells. As shown inFigure 13C, the miR-148a-5p mimic significantly decreased luciferase activity compared to control miRNA, while TLR3-mt led to complete abrogation of the negative effect. These ...
and we can see that the difference between the expressions has disappeared, since theIgnoreCasevariants are being transformed to be identical to their counterparts. It's also interesting to note that the first benchmark not only trippled in throughput to match the set-based expression, they both...
Yeast was the first microorganism used by mankind for biotransformation of feedstock that laid the foundations of industrial biotechnology. Long historical use, vast amount of data, and experience paved the way for Saccharomyces cerevisiae as a first yea