Co-expression correlations provide the ability to predict gene functionality within specific biological contexts, such as different tissue and disease conditions. However, current gene co-expression databases generally do not consider biological context.
Accordingly, MCT-1 gene induction is recognized as a potential biomarker of breast tumor development. Abrogating MCT-1 function may be a promising stratagem for management of breast cancer involving Src hyperactivation and/or PTEN dysfunction. Oncogene (2014) 33, 5109–5120; doi:10.1038/onc....
A growing number of studies have been reporting that the expression level of RGs may vary in dif- ferent organisms or experimental conditions. Even the most commonly used HKG cannot be assumed to a universally applicable RG; its behavior in different cancers, tissues, or cells must be ...
35 Without TP53 protein in the NPC-TW06 nucleus, the NOLC1 gene cannot be up-regulated by EBV infection, which suggests that TP53 plays some role in the regulation of NOLC1 gene expression after EBV infection in NPC cells. Previous studies have reported the development of NPC to be unlike...
As with other systems, possible side-effects cannot be excluded and have to be assessed for each specific application. Here, no off-target effects concerning the dimerized transcription factor components or rapalog treatment alone could be observed in two independent biological assay conditions (Fig....
In contrast, the HPV-16 E5 protein, an 83-amino-acid, membrane-associated protein Bubb et al 1988, Conrad et al 1993, Halbert and Galloway 1988, cannot immortalize primary cells from either human or mouse species. However, HPV-16 E5 can enhance the immortalization of keratinocytes by E6/E7...
The function of extracted genes was sorted based on the analytical program of Database for Annotation Visualization and Integrated Discovery.8 Real-Time PCR Real-time PCR was performed as described previously.9 Briefly, the total RNA extracted from the same RNA pool of microarray was used as the...
Acanthamoebae are potentially pathogenic organisms, with a highly unique, yet still insufficiently investigated metabolism. Many open questions can be addressed by gene expression studies, however, for Acanthamoeba reliable standards have not yet been es
One particular group of toxins exerts its action by blocking protein synthesis either by directly modifying elongation factor 2 (EF-2) or by modifying the ribosome itself so that EF-2 cannot function in protein synthesis. This class of toxins, ribo some-inactivating proteins (RIPs), can be ...
This route of administration, usually called “regional (loco-regional) infusion”, “administration by isolated limb perfusion” or “high-pressure transvenous limb perfusion” has been successfully used as a gene delivery method in muscular dystrophy. According to one aspect, the composition is ...