ayes you need to sign out of the one first and sign into the other and yes you click the button 是您需要签字在一一个外面和标志入其他和您是点击按钮[translate] adysfunction in part by increasing expression of zonula 官能不良一部分通过增加zonula表示[translate]...
G protein-coupled receptors are seven transmembrane signaling molecules that are involved in a wide variety of physiological processes. They constitute a large protein family of receptors with almost 300 members detected in human pancreatic islet preparations. However, the functional role of these recepto...
Autism spectrum disorder (ASD) is more prevalent in males, and the mechanisms behind this sex-differential risk are not fully understood. Two competing, but not mutually exclusive, hypotheses are that ASD risk genes are sex-differentially regulated, or a
Together, these studies in humans and mice support a general hypothesis of GABA dysfunction in MDD and point to sex chromosome complement as a potential modulator. Serotonin and dopamine in MDD Along with evidence for dysfunction in fast-acting GABA neurotransmission in MDD, evidence also suggests ...
Diabetic erectile dysfunction (ED) has multiple causative factors, such as endothelial and smooth muscle dysfunction and cavernous fibrosis. Wnt signalling is essential for normal embryonic development and for tissue homeostasis in adults. Aberrant activation of Wnt family members has been implicated in ...
A case report is given about two male in... L Schuchmann,JP Colombo,H Fischer - 《Klinische Pädiatrie》 被引量: 5发表: 1980年 [Hyperammonemia in the newborn through ornithine transcarbamylase deficiency (author's transl)] This is a report of a family with in the newborn, very ...
This study aimed to investigate how IFN-γ impairs the endothelial barrier integrity by specifically examining the roles of caldesmon, adherens junctions (AJs) and p38 mitogen-activated protein (MAP) kinase in IFN-γ-induced endothelial barrier dysfunction. IFN-γ exhibited a biphasic effect on ...
Homozygous deletion of BAG3 in mice led to severe LV dysfunction,myofibrildisorganization, and death by 4 weeks of age(7); however, the molecular mechanisms responsible for regulation of BAG3 function in the heart are just beginning to be understood. For example, knock down of BAG3 in cultur...
In addition, unbiased analysis of global gene expression using RNA-seq revealed that loss of the APP family alters the transcription profile in the adult mouse cerebral cortex. These findings represent an initial step toward a more complete understanding of the role of APP family genes in the ...
Improved understanding of the molecular mechanisms responsible for the progression from a “non-pathogenic” steatotic state to Non-Alcoholic Steatohepatitis is an important clinical requirement. The cell death-inducing DFF45 like effector (CIDE) family