Microfilm recordion of military unit histories is complete for prostate cancer cases and controls and in progress for comparison cancers. Exposure assessments in progress are the basis for studies of prostate cancer risk in relation to exposure to dioxin-contaminated phenoxy and other herbicides in Vietnam.S. Stellman
Previous rat studies have demonstrated the ability of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)) exposure to promote the epigenetic transgenerational inheritance of disease susceptibility in subsequent generations. The types of disease previously observed include puberty abnormalities, testis, ...
Following administration to pregnant rats, DDE was shown to cause feminization in the male offspring at the neonatal stages but did not affect the pubertal growth of accessory sex organs. In this study, we examined the potential of in utero exposure to antiandrogens to alter the responsiveness ...
The term “dioxins” is commonly used to refer a group of 75 polychlorinated dibenzo-p-dioxins (PCDDs) and 135 polychlorinated dibenzofurans (PCDFs) congeners among which less than 20 are believed to be toxic. Dioxin like-PCBs (dl-PCBs) refer to 12 non-orthoor mono-orthoPCBs exhibiting si...
In 1991, Congress enacted the Agent Orange Act, giving the Department of Veterans Affairs the authority to declare certain conditions “presumptive” to exposure to Agent Orange/dioxin, making these veterans who served in Vietnam eligible to receive treatment and compensation for these conditions. ...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically known for its toxic responses to man-made pollutants such as dioxin. More recently, the AhR has emerged as a suppressor of inflammation, oxidative stress and apoptosis from cigarette smoke by mechanisms that ...
years and is highly resistant to either biological or chemical degradation (Sorg et al.2009). Therefore, dioxin has significant environmental persistence and bioaccumulation. Among occupationally exposed populations in New Zealand, TCDD was associated with an increased risk of diabetes and a series of ...
on the Adult Heart received: 11 April 2016 accepted: 01 September 2016 Published: 28 September 2016 Xiefan Fang, Ryan R. Poulsen, Scott A. Rivkees & Christopher C. Wendler Each year millions of pregnant woman are exposed to caffeine, which acts to antagonize adenosine action...
Agent Orange, or 2,3,7,8-tetrachlorodibenzodioxin, has been shown to cause indirect DNA damage, producing malignancies. However, its connection to nonmelanotic invasive skin cancer is unclear. This study investigated whether 2,3,7,8-tetrachlorodibenzodioxin exposure increases the incidence of ...
(Kumar et al., 2020). Short-term exposure to high levels dioxins has been reported to alter liver function in humans. Chronic exposure to dioxin compounds for a long leads to impairment of the immune system. Exposure to high levels of dioxins has been reported to causeskin lesionsand patchy...