2.4.1Exportin 5 The proteinexportin 5(Exp5; encoded byXPO5) forms a transport complex with GTP-binding nuclear protein RAN/GTP and a pre-miRNA[42]. When there is a translocation through the nuclear pore, GTP is hydrolyzed, resulting in the disassembly of the complex and release of the pr...
XPO5(Exportin-5)是一种重要的核运输蛋白,在细胞核-细胞质转运过程中起着关键作用。该蛋白负责运输miRNA和tRNA等小分子RNA通过核孔蛋白复合物转运至细胞质,发挥调控基因表达和蛋白合成的重要功能。目录号 PA1000-9226 XPO5基本信息:XPO5编码的基因位于人类染色体2号,全长约1477个氨基酸,分子量约为168kDa。该...
Exportin 5 (XPO5) is a member of the importin β family of proteins (2) and functions in tRNA export in a sequence dependent fashion. More recently, it has been shown to export pre-miRNA by a RanGTPase-driven process from the nucleus to the cytoplasm, where pre-miRNA processing occurs ...
中文名称:Exportin 5核输出蛋白5抗体 英文名称:Anti-Exportin 5 别名:Exp 5; Exp5; Exportin 5; Exportin-5; Exportin5; FLJ14239; FLJ32057; FLJ45606; KIAA1291; Ran binding protein 21; Ran-binding protein 21; Ranbp 21; Ranbp21; Xpo 5; xpo5; XPO5_HUMAN. ...
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目的探讨宫颈脱落细胞中 Ki67 和 exportin-5 的表达用于宫颈癌筛查的价值.方法 3 000 例同时行液基薄层细胞学检查( TCT)和杂交捕获Ⅱ代法人乳头瘤病毒( HPV HC -Ⅱ)检测的患者,按 TCT 结果分为 4 组,采用免疫荧光双标法检测各组宫颈脱落...
ERK Exportin-5 Pin1 nuclear export miRNA global downregulation liver cancer miR-122 drug resistance microtubule Significance Systemic analysis of miRNAs has revealed that many pre-miRNAs are retained in the nucleus of cancer cells. In this study, we have identified that ERK phosphorylation coupled wit...
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Exportin5 (Exp5) is the major miRNA nuclear export factor and recognizes structural features of pre-miRNA hairpins, while it also exports other minihelix-containing RNAs. InDrosophila,Exp5 is suggested to play a major role in tRNA export because the gene encoding the canonical tRNA export facto...