I needed a way to be able to test the PEFILE.DLL functions, which in some cases required multiple file views simultaneously--hence the multiple view support. Second, much of the work of figuring out
Going back to this notion of raw data is where things get really interesting. You have an XML file that specifies a potentially very complex animation on a frame-by-frame basis. Of course with ActionScript 3 you also have native XML processing and E4X support. This means that you can chang...
These data are consistent with the notion that Puf6 removal from the 60S pre-ribosome precedes Nog2 recruitment. We suggest that Rix1-TAP purifies a state of a 60S pre-ribosome that is loaded with Puf6, and a later state wherein Puf6 has been evicted and Nog2 has been recruited. Pu...
Consistent with this notion, splicing and export of snRNA and mRNA can be inhibited by exogenously providing cap analogues2–4. The RNA cap structure is bound by the highly conserved nuclear cap-binding complex (CBC), a central factor, known to orchestrate most downstream RNA biogenesis processes...
In the S. typhimurium SctRSTU complex, the corresponding residue strongly photocrosslinks to SctS (Supplementary Fig. 4), sup- porting the notion that SctU mediates gating of the EA core complex. We decided to further probe the function of FlhBL using mutagenesis in the motile Escherichia coli...
(FlhBP28inS.typhimuriumand FlhBA28inV. mimicus) locates very close to the pore entrance (Supplementary Fig.10). In theS.typhimuriumSctRSTU complex, the corresponding residue strongly photocrosslinks to SctS (Supplementary Fig.4), supporting the notion that SctU mediates gating of the EA core ...
to cytoplasm was seen under refeeding conditions (Fig.2b–d), supporting the notion that nuclear export is an important modulator of TFEB subcellular localization. Notably, under starvation conditions, a fraction of nuclear TFEB still redistributed from nucleus to cytosol (Fig.2b–d), further ...
dynamics rather than by regulating YAP abundance. To prove this notion directly, cells were transfected with DVL3 expression vector and the nuclear YAP compartmentalization was assessed. Indeed, DVL3 significantly depleted nuclear YAP abundance in 293 and MCF-7 cells (Fig.2b). The YAP has ...
This notion is particularly interesting in light of the fact that Nup214 may exert its stabilizing effect on export complexes by keeping Crm1 in the toroid-conformation associated with Ran- and cargo-binding43. Similarly, Yrb2p-binding to Xpo1 (and to Gsp1p-GTP), which primes the transport ...
We build on and extend the latter notion by assuming that both firm-level product quality and productivity are stochastic but not independently so. Specifically, we consider (λ̃frcht,ϕ̃frcht) to be distributed bivariate Pareto of the so-called first type (see Mardia, 1962). Let λ...