In order to reveal the essence of the pharmaceutical incompatibility, the cooperativity effects of the drug–drug intermolecular π???π and H???O H-bonding interactions involving hydration were evaluated in the phenobarbital???paracetamol???H2O complex at the M06-2X/6–311++G** and MP2/6...
Ligand-dependent transcription factor pregnane X receptor (PXR) is responsible for controlling Cytochrome P450 3A4 (CYP3A4) expression, and this regulation is connected to specific herb-drug interactions. A new investigation found Gou Teng to be associated with the induction of CYP3A4 expression, ...
The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors SHP (short heterodimer partner) is an unusual orphan nuclear receptor consisting only of a ligand-binding domain, and it exhibits unique features of intera... L Johansson,A...
It relies on interactions between episodic memory, associated emotions, an... M Piefke,GR Fink - 《Anatomy & Embryology》 被引量: 120发表: 2005年 Virtual reality to maximize function for hand and arm rehabilitation: exploration of neural mechanisms. Stroke patients report hand function as the ...
In physiological environments, lipoplexes are coated by a protein corona (PC) that mediates the interactions with the cell machinery. Here we show that the formation of PC can change the interactions of multicomponent (MC) lipoplexes with our cell model (i.e., HeLa). At the highest lipoplex...
Even Jones’s description reveals the causal nature of this case. He states that “[t]he directionality of cellular interactions within the immune system pathway determines the pathway’s bowtie structure: various stimuli activate pathways that converge to activate naive CD4+ T cells, which in tur...
In scenarios involving numerous features and intricate relationships, SHAP has demonstrated superior performance compared to alternative methods, effectively disentangling complex interactions and providing a clearer understanding of the factors driving predictions [50]. Furthermore, SHAP’s foundation in ...
Thisis appropriate for weak-theory domains where the details of the causal interactionsin the domain are not well understood; experts would howeverbe able to express the direction of causal interactions. In this paper wepresent such a knowledge-light framework for Case-Based Explanation. 展开 关键...
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This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consist