Our models allow us to develop working hypotheses regarding how T-cell function is regulated through structural modulations of catch and slip bonds. For example, in this study we validated a prediction of the class I model that strengthening of the α1α2–β2m interdomain bond would weaken th...
Here, we have used an optical-tweezers-based transducer to measure the effect of load on the mechanical interactions between rabbit skeletal F-actin and a single head of mouse brain myosin-V, which produces its working stroke in two phases. We found that the lifetimes of the first phase ...
Some optical mice have two LEDs. The first one shines light down onto the desk. The light from that is picked up by the photocell. The second LED lights up a red plastic strip along the back of the mouse so you can see it's working. Most optical mice also have a wheel at the ...