Comparing to a generic two-state model, our models can distinguish class I from class II MHCs and correlate their structural parameters with the TCR/pMHC’s potency to trigger T cell activation. The models are tested by mutagenesis using an MHC and a TCR mutated to alter conformation changes....
is not fully understood. Here, we report that in HeLa cells and activated CD4+T cells infected with HIV-1 pseudotyped with VSV-G and native Env protein, respectively, Rab7+late endosomes containing endocytosed HIV-1 promote the formation of nuclear envelope invaginations (NEIs...
Seoul has undergone significant changes in land use and land cover. With most of the forest vegetation destroyed during the Korean War (1950 – 1953), afforestation projects were established to cover barren land from the 1960 s to the 1970 s (Hong et al., 2013). Many housing development pr...
The values of R.M.S.D., space group and fibrillogenic potential are shown in Table S2. Also, in Fig. S2 all superimposed subunits are shown. The values of R.M.S.D. in general, they are very similar (0.19–0.85 Å), independently whether the 6aJL2 proteins form the ...
directions of effects would support the idea of enhanced multisensory integration with ageing13. Second, we investigated potential dependencies between multisensory integration, sensory capability and cognitive status. Therefore, preceding the experiment, we estimated unimodal visual and tactile thresholds and...
Moreover, we showed the potential mechanism of enzalutamide with its different antiviral activity in the human prostate and lung. Results TMPRSS2 plays a crucial role in promoting SARS-CoV-2 infection To elucidate whether TMPRSS2 is crucial for SARS-CoV-2-driven entry into host cells in vivo...
This is likely correlated with the potential of mean force (PMF) results discussed in detail below. The average number of H-bonds in each mutant structure is the same over the course of each simulation, as are the average hydrophobic solvent-accessible surface (h-sasa) in the closed and ...
The proposed case studies were thoroughly analyzed highlighting how the production process impacts on sustainability and pointing out potential best practices and key performance indicators. The key conclusion of this study is, on the one hand, to depict the current set of sustainable best practices ...
Because of the high temperatures registered at our field sites, the potential strong impact of heat on photosynthesis [34], and because periodic extreme leaf temperatures may induce higher temperature photosynthetic acclimation [39–41]; we would expect species in this environment to present mechanisms...